Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Ajith P.K. Nissanka; Veranja Karunaratne; B. M.Ratnayake Bandara; Vijaya Kumar; Tsutomu Nakanishi; Masatoshi Nishi; Akira Inada; L. M.V. Tillekeratne; D. S.A. Wijesundara; A. A.Leslie Gunatilaka

doi:10.1016/S0031-9422(00)00402-7

Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Ajith P.K. Nissanka
, Veranja Karunaratne
, B. M.Ratnayake Bandara
, Vijaya Kumar
, Tsutomu Nakanishi
, Masatoshi Nishi
, Akira Inada
, L. M.V. Tillekeratne
, D. S.A. Wijesundara
, A. A.Leslie Gunatilaka

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

Original language	English (US)
Pages (from-to)	857-861
Number of pages	5
Journal	Phytochemistry
Volume	56
Issue number	8
DOIs	https://doi.org/10.1016/S0031-9422(00)00402-7
State	Published - Apr 12 2001

Keywords

8-Acetonyldihydroavicine
8-Acetonyldihydronitidine
Antimicrobial
Benzophenanthrene alkaloids
Insecticidal
Rutaceae
Spermicidal
Z. caudatum
Zanthoxylum tetraspermum

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(00)00402-7

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title = "Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum",

abstract = "Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.",

keywords = "8-Acetonyldihydroavicine, 8-Acetonyldihydronitidine, Antimicrobial, Benzophenanthrene alkaloids, Insecticidal, Rutaceae, Spermicidal, Z. caudatum, Zanthoxylum tetraspermum",

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year = "2001",

month = apr,

day = "12",

doi = "10.1016/S0031-9422(00)00402-7",

language = "English (US)",

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pages = "857--861",

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AU - Nissanka, Ajith P.K.

AU - Karunaratne, Veranja

AU - Bandara, B. M.Ratnayake

AU - Kumar, Vijaya

AU - Nakanishi, Tsutomu

AU - Nishi, Masatoshi

AU - Inada, Akira

AU - Tillekeratne, L. M.V.

AU - Wijesundara, D. S.A.

AU - Gunatilaka, A. A.Leslie

PY - 2001/4/12

Y1 - 2001/4/12

N2 - Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

AB - Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-γ,γ-dimethylallylether. The-species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.

KW - 8-Acetonyldihydroavicine

KW - 8-Acetonyldihydronitidine

KW - Antimicrobial

KW - Benzophenanthrene alkaloids

KW - Insecticidal

KW - Rutaceae

KW - Spermicidal

KW - Z. caudatum

KW - Zanthoxylum tetraspermum

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M3 - Article

C2 - 11324918

AN - SCOPUS:0035849159

SN - 0031-9422

VL - 56

SP - 857

EP - 861

JO - Phytochemistry

JF - Phytochemistry

IS - 8

ER -

Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum

Abstract

Keywords

ASJC Scopus subject areas

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