Antigen solubilized from human leukemia: Lymphocyte stimulation

Jordan U. Gutterman, Giora Mavligit, Kenneth B. McCredie, Gerald P. Bodey, Emil J. Freireich, Evan M. Hersh

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Soluble antigen was extracted with hypertonic (3 molar) potassium chloride from the malignant cells of seven patients with acute leukemnia. The antigen and leukemia cells were used to stimulate autologous patients' and allogeneic normal donors' lymphocytes in mixed lymphocyte cultuires. The lymphocytes of six patients showed significant blastogenic responses to autologolus antigen. In contrast, the lymphocytes of only one of seven normal donors responded to the soluble antigens. Both patients' and normal subjects' lymphocytes responded to the intact leukemia cells. The use of these antigens should facilitate the study of specific tumor immunity in human leukemia.

Original languageEnglish (US)
Pages (from-to)1114-1115
Number of pages2
Issue number4054
StatePublished - 1972

ASJC Scopus subject areas

  • General


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