TY - JOUR
T1 - Antidiabetic effects of Justicia spicigera Schltdl (Acanthaceae)
AU - Ortiz-Andrade, Rolffy
AU - Cabañas-Wuan, Angel
AU - Arana-Argáez, Víctor E.
AU - Alonso-Castro, Angel Josabad
AU - Zapata-Bustos, Rocio
AU - Salazar-Olivo, Luis A.
AU - Domínguez, Fabiola
AU - Chávez, Marco
AU - Carranza-Álvarez, Candy
AU - García-Carrancá, Alejandro
N1 - Funding Information:
AJAC ( 174493 ) and RZB ( 233280 ) were endowed with graduate fellowships from CONACYT . Thank to Merck Sharp & Dohme, México, for providing Indinavir. This work was partially supported by CONACYT, México (Grant SALUD-2009-01-114435 to LSO).
PY - 2012/9/28
Y1 - 2012/9/28
N2 - Ethnopharmacological importance: Justicia spicigera is a plant species used for the Teenak (Huesteca Potosina) and Mayan (Yucatan peninsula) indigenous for the empirical treatment of diabetes, infections and as stimulant. Aim of the study: To evaluate the cytotoxicity, antioxidant and antidiabetic properties of J. spicigera. Materials and methods: The effects of ethanolic extracts of J. spicigera (JSE) on the glucose uptake in insulin-sensitive and insulin-resistant murine 3T3-F442A and human subcutaneous adipocytes was evaluated. The antioxidant activities of the extract of JSE was determined by ABTS and DPPH methods. Additionally, it was evaluated the antidiabetic properties of JSE on T2DM model. Results: JSE stimulated 2-NBDG uptake by insulin-sensitive and insulin-resistant human and murine adipocytes in a concentration-dependent manner with higher potency than rosiglitazone 1 mM. JSE showed antioxidant effects in vitro and induced glucose lowering effects in normoglycemic and STZ-induced diabetic rats. Conclusion: The antidiabetic effects of administration of J. spicigera are related to the stimulation of glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes and this evidence justify its empirical use in Traditional Medicine. In addition, J. spicigera exerts glucose lowering effects in normoglycemic and STZ-induced diabetic rats.
AB - Ethnopharmacological importance: Justicia spicigera is a plant species used for the Teenak (Huesteca Potosina) and Mayan (Yucatan peninsula) indigenous for the empirical treatment of diabetes, infections and as stimulant. Aim of the study: To evaluate the cytotoxicity, antioxidant and antidiabetic properties of J. spicigera. Materials and methods: The effects of ethanolic extracts of J. spicigera (JSE) on the glucose uptake in insulin-sensitive and insulin-resistant murine 3T3-F442A and human subcutaneous adipocytes was evaluated. The antioxidant activities of the extract of JSE was determined by ABTS and DPPH methods. Additionally, it was evaluated the antidiabetic properties of JSE on T2DM model. Results: JSE stimulated 2-NBDG uptake by insulin-sensitive and insulin-resistant human and murine adipocytes in a concentration-dependent manner with higher potency than rosiglitazone 1 mM. JSE showed antioxidant effects in vitro and induced glucose lowering effects in normoglycemic and STZ-induced diabetic rats. Conclusion: The antidiabetic effects of administration of J. spicigera are related to the stimulation of glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes and this evidence justify its empirical use in Traditional Medicine. In addition, J. spicigera exerts glucose lowering effects in normoglycemic and STZ-induced diabetic rats.
KW - Antioxidant
KW - Cytotoxic
KW - Diabetes
KW - Glucose uptake
KW - Justicia spicigera
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U2 - 10.1016/j.jep.2012.06.043
DO - 10.1016/j.jep.2012.06.043
M3 - Article
C2 - 22819688
AN - SCOPUS:84866005585
SN - 0378-8741
VL - 143
SP - 455
EP - 462
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 2
ER -