Antidiabetic effects of Justicia spicigera Schltdl (Acanthaceae)

Rolffy Ortiz-Andrade, Angel Cabañas-Wuan, Víctor E. Arana-Argáez, Angel Josabad Alonso-Castro, Rocio Zapata-Bustos, Luis A. Salazar-Olivo, Fabiola Domínguez, Marco Chávez, Candy Carranza-Álvarez, Alejandro García-Carrancá

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Ethnopharmacological importance: Justicia spicigera is a plant species used for the Teenak (Huesteca Potosina) and Mayan (Yucatan peninsula) indigenous for the empirical treatment of diabetes, infections and as stimulant. Aim of the study: To evaluate the cytotoxicity, antioxidant and antidiabetic properties of J. spicigera. Materials and methods: The effects of ethanolic extracts of J. spicigera (JSE) on the glucose uptake in insulin-sensitive and insulin-resistant murine 3T3-F442A and human subcutaneous adipocytes was evaluated. The antioxidant activities of the extract of JSE was determined by ABTS and DPPH methods. Additionally, it was evaluated the antidiabetic properties of JSE on T2DM model. Results: JSE stimulated 2-NBDG uptake by insulin-sensitive and insulin-resistant human and murine adipocytes in a concentration-dependent manner with higher potency than rosiglitazone 1 mM. JSE showed antioxidant effects in vitro and induced glucose lowering effects in normoglycemic and STZ-induced diabetic rats. Conclusion: The antidiabetic effects of administration of J. spicigera are related to the stimulation of glucose uptake in both insulin-sensitive and insulin-resistant murine and human adipocytes and this evidence justify its empirical use in Traditional Medicine. In addition, J. spicigera exerts glucose lowering effects in normoglycemic and STZ-induced diabetic rats.

Original languageEnglish (US)
Pages (from-to)455-462
Number of pages8
JournalJournal of Ethnopharmacology
Volume143
Issue number2
DOIs
StatePublished - Sep 28 2012
Externally publishedYes

Keywords

  • Antioxidant
  • Cytotoxic
  • Diabetes
  • Glucose uptake
  • Justicia spicigera

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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