@article{703236ee6e454c99b4bdbeffb2fd6443,
title = "ANTIBODIES TO LYMPHOCYTES IN CANCER",
author = "Ablin, \{R. J.\}",
note = "Funding Information: certain infections and certain neoplasias. If genetic inheritance of lymphocytic sensitisation to specific allergens is presumed in the cases of the 2 babies whose mothers were non-atopic and lacked lymphocytic sensitisation to the same allergens, the babies could have inherited the specific genotype from both parents (the mothers being carriers of one such recessive genotype) or could possess a dominant gene whose expression is sup- pressed by modifying genes. That newborns can inherit their maternal lymphocytes is likely, since maternal peripheral lymphocytes, particularly the small lymphocyte, can cross the placental barrier at all stages of fetal development-notably during its early phases, when bone-marrow primordial stem-cells are dif- ferentiating. Competent maternal peripheral lymphocytes can induce genomic maturation of specific loci of fetal lymphocytic primordial cells, either through direct cell-to- cell transfer of a certain genetic factor or through partial hybridisation between a competent maternal lymphocyte and the undifferentiated fetal lymphoid-cell progenitor. Such a mechanism of direct induction of fetal-lymphocyte sensitisation could ensure sensitisation of the newborn baby to antigens for which his mother was genetically primed as well as to those antigens prevailing in her environment to which she was actively sensitised. It is noteworthy that the in-vitro peripheral-lymphocyte transformation response to the tested allergens cannot be attributed to the presence in such extracts of a nonspecific lymphocytic mitogen (except in batches of grass extracts). This work was assisted by grants 4 x 2507 and 03-007-1 from the National Institutes of Health, Bethesda, Maryland, U.S.A. Medical Genetics Unit and Pediatrics Department, Ain-Shames University, Cairo, Egypt. NEMAT HASHEM.",
year = "1972",
month = jan,
day = "1",
doi = "10.1016/S0140-6736(72)90032-3",
language = "English (US)",
volume = "299",
pages = "41",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier B.V.",
number = "7740",
}