TY - JOUR
T1 - Antiarrhythmic Efficacy of Desipramine
AU - Fenster, Paul E.
AU - Bressler, Rubin
AU - Kipps, Julie
PY - 1989/2
Y1 - 1989/2
N2 - The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single‐blind, placebo‐controlled, dose‐ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, based on three 24 hour ambulatory ECGs obtained on each dose. Among seven patients with analyzable data, one responded to 75 mg daily, and three others responded to 150 mg daily. Six of the seven patients demonstrated decreases in VED frequency with increases in desipramine serum concentration. Among five patients with episodes of nonsustained ventricular tachycardia, desipramine completely abolished the episodes in two, and reduced the frequency of episodes by at least 90% in two others. Adverse reactions were common, and necessitated drug discontinuation or dose reduction in five patients. Desipramine has an antiarrhythmic effect in patients with chronic ventricular ectopy, but its clinical utility is limited by adverse effects. 1989 American College of Clinical Pharmacology
AB - The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single‐blind, placebo‐controlled, dose‐ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, based on three 24 hour ambulatory ECGs obtained on each dose. Among seven patients with analyzable data, one responded to 75 mg daily, and three others responded to 150 mg daily. Six of the seven patients demonstrated decreases in VED frequency with increases in desipramine serum concentration. Among five patients with episodes of nonsustained ventricular tachycardia, desipramine completely abolished the episodes in two, and reduced the frequency of episodes by at least 90% in two others. Adverse reactions were common, and necessitated drug discontinuation or dose reduction in five patients. Desipramine has an antiarrhythmic effect in patients with chronic ventricular ectopy, but its clinical utility is limited by adverse effects. 1989 American College of Clinical Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=0024600928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024600928&partnerID=8YFLogxK
U2 - 10.1002/j.1552-4604.1989.tb03297.x
DO - 10.1002/j.1552-4604.1989.tb03297.x
M3 - Article
C2 - 2654200
AN - SCOPUS:0024600928
SN - 0091-2700
VL - 29
SP - 114
EP - 117
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
IS - 2
ER -