Anti-tumor activity and mechanism of action for a cyanoaziridine- derivative, AMP423

Keyphrases

• Mechanism of Action 100%
• Antitumor Activity 100%
• Antitumor Effect 100%
• Imexon 100%
• SCID Mice 50%
• Cancer Cell Lines 50%
• Tumor-bearing Mice 50%
• Nontumor 50%
• Myeloma 50%
• Cytotoxic Potency 50%
• Mechanistic Studies 25%
• Tumor 25%
• Pharmacokinetics 25%
• Sulfhydryl 25%
• Apoptosis 25%
• Antitumor Agents 25%
• Myeloma Cells 25%
• Necrosis 25%
• Alkylation 25%
• Resistant Variants 25%
• Cell Cycle Arrest 25%
• Reactive Oxygen Species Production 25%
• Nucleophile 25%
• Sigma Phase 25%
• Xenograft 25%
• Toxicology 25%
• Tumor Inhibition 25%
• Structural Analogues 25%
• Human Lymphoma 25%
• Carboxamide 25%
• Naphthyl 25%
• B-cell Lymphoma 25%
• Myelosuppressive 25%
• Protein Synthesis Inhibition 25%
• Hematological Cancer 25%
• Pro-oxidant 25%
• In Vivo Activity 25%
• Cell Death Pathways 25%
• Tumor Growth Delay 25%
• Mechanism of Action Studies 25%
• Pro-oxidant Effect 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Neoplasm 100%
• Imexon 50%
• Myeloma 37%
• Malignant Neoplasm 25%
• Mouse 25%
• Oxidizing Agent 25%
• SCID Mouse 25%
• Pharmacokinetics 12%
• Reactive Oxygen Metabolite 12%
• Thiol Derivative 12%
• Tumor Growth 12%
• Necrosis 12%
• Preclinical Study 12%
• Carboxamide 12%
• Nucleophile 12%
• Naphthalene 12%
• B Cell Lymphoma 12%
• Cancer Inhibition 12%