Abstract
LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 307-319 |
| Number of pages | 13 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
Keywords
- Apoptosis
- Cytokine
- Immune dysfunction
- Murine retrovirus
- T and B cell proliferation
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Toxicology
- Pharmacology