Antegrade versus retrograde perfusion of the donor lung: Impact on the early reperfusion phase

Theo Kofidis, Martin Strüber, Gregor Warnecke, Sebastian Sommer, Rainer G. Leyh, Leora B. Balsam, Robert C. Robbins, Axel Haverich

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Transpulmonary thermodilution was used to evaluate the effect of flush route during harvest on hemodynamic and respiratory function of the pulmonary graft in the early post-transplant phase. Single lung transplantation was performed in two piglet groups after 24 h of cold storage. Donor organs for group A underwent antegrade perfusion, and those for group R retrograde perfusion. PaO2, compliance (C), airway resistance (R), extravascular lung water index (EVLWI), pulmonary blood volume index (PBVI), intrathoracic blood volume index (ITBVI), capillary leak (CL), and cardiac function index (CFI) were assessed by transpulmonary thermodilution at baseline, 1, 3, and 6 h after reperfusion. EVLWI was significantly lower in group R. Compliance and PaO2 were higher in the same group. The two groups did not differ significantly with regard to CFI, PBVI, ITBVI, and airway resistance. Retrograde perfusion of the donor lung had a positive impact on graft function during early reperfusion. Transpulmonary hemodynamic monitoring can be a powerful tool for intra- and postoperative management of transplant patients.

Original languageEnglish (US)
Pages (from-to)801-805
Number of pages5
JournalTransplant International
Volume16
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Keywords

  • Lung transplantation
  • Organ harvest
  • Retrograde flush perfusion
  • Transpulmonary thermodilution

ASJC Scopus subject areas

  • Transplantation

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