TY - JOUR
T1 - Antegrade versus retrograde perfusion of the donor lung
T2 - Impact on the early reperfusion phase
AU - Kofidis, Theo
AU - Strüber, Martin
AU - Warnecke, Gregor
AU - Sommer, Sebastian
AU - Leyh, Rainer G.
AU - Balsam, Leora B.
AU - Robbins, Robert C.
AU - Haverich, Axel
PY - 2003/11
Y1 - 2003/11
N2 - Transpulmonary thermodilution was used to evaluate the effect of flush route during harvest on hemodynamic and respiratory function of the pulmonary graft in the early post-transplant phase. Single lung transplantation was performed in two piglet groups after 24 h of cold storage. Donor organs for group A underwent antegrade perfusion, and those for group R retrograde perfusion. PaO2, compliance (C), airway resistance (R), extravascular lung water index (EVLWI), pulmonary blood volume index (PBVI), intrathoracic blood volume index (ITBVI), capillary leak (CL), and cardiac function index (CFI) were assessed by transpulmonary thermodilution at baseline, 1, 3, and 6 h after reperfusion. EVLWI was significantly lower in group R. Compliance and PaO2 were higher in the same group. The two groups did not differ significantly with regard to CFI, PBVI, ITBVI, and airway resistance. Retrograde perfusion of the donor lung had a positive impact on graft function during early reperfusion. Transpulmonary hemodynamic monitoring can be a powerful tool for intra- and postoperative management of transplant patients.
AB - Transpulmonary thermodilution was used to evaluate the effect of flush route during harvest on hemodynamic and respiratory function of the pulmonary graft in the early post-transplant phase. Single lung transplantation was performed in two piglet groups after 24 h of cold storage. Donor organs for group A underwent antegrade perfusion, and those for group R retrograde perfusion. PaO2, compliance (C), airway resistance (R), extravascular lung water index (EVLWI), pulmonary blood volume index (PBVI), intrathoracic blood volume index (ITBVI), capillary leak (CL), and cardiac function index (CFI) were assessed by transpulmonary thermodilution at baseline, 1, 3, and 6 h after reperfusion. EVLWI was significantly lower in group R. Compliance and PaO2 were higher in the same group. The two groups did not differ significantly with regard to CFI, PBVI, ITBVI, and airway resistance. Retrograde perfusion of the donor lung had a positive impact on graft function during early reperfusion. Transpulmonary hemodynamic monitoring can be a powerful tool for intra- and postoperative management of transplant patients.
KW - Lung transplantation
KW - Organ harvest
KW - Retrograde flush perfusion
KW - Transpulmonary thermodilution
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U2 - 10.1111/j.1432-2277.2003.tb00244.x
DO - 10.1111/j.1432-2277.2003.tb00244.x
M3 - Article
C2 - 12856115
AN - SCOPUS:0345098543
SN - 0934-0874
VL - 16
SP - 801
EP - 805
JO - Transplant International
JF - Transplant International
IS - 11
ER -