Angiotensin 1-7 stimulation of platelet recovery

Kathleen E. Rodgers, Kainoa J. Peterson, Holly A. Maulhardt, Gere S. Dizerega

Research output: Contribution to journalArticlepeer-review


Introduction: Thrombocytopenia is an abnormally low number of platelets in the blood resulting from either too few platelets being produced or existing platelets being destroyed. Severe thrombocytopenia leads to excessive bleeding and can be the result of numerous medical conditions or a side effect of medications or treatments. Although platelet transfusions are typically administered to correct thrombocytopenia, transfusions represent a temporary and unsustainable solution. As there is a limited supply of platelet units available for transfusion, along with the significant financial cost and risk of infection, investigation to uncover mechanisms that boost platelet production may have important clinical and therapeutic implications. Treatment with angiotensin 1-7 (A(1-7)) has been shown in a preclinical and clinical evaluations to have a positive effect on platelet recovery. Areas covered: The authors provide an overview of the current treatment options available for platelet recovery and highlight the need for alternatives. Following on, the authors discuss the use of A(1-7) as a potential therapeutic option for platelet recovery, including its safety and efficacy. Expert opinion: Current evidence provides a good basis for continued research and evaluation of the benefits of A(1-7) treatment in stimulating platelet recovery following myelosuppression. A(1-7) therapy has the potential to make a significant contribution to healthcare by providing standalone and additive treatments to address unmet medical needs and life-threatening diseases by utilizing the regenerative arm of the renin-angiotensin system.

Original languageEnglish (US)
Pages (from-to)551-559
Number of pages9
JournalExpert Opinion on Investigational Drugs
Issue number4
StatePublished - Apr 2014
Externally publishedYes


  • Angiotensin (1-7)
  • Filgrastim
  • Hematopoiesis
  • Hematopoietic stem cell
  • Myelosuppression
  • Platelet recovery
  • Thrombocytopenia
  • TXA127

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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