TY - JOUR
T1 - Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo
AU - Heringer-Walther, Silvia
AU - Eckert, Klaus
AU - Schumacher, Sarah Mai
AU - Uharek, Lutz
AU - Wulf-Goldenberg, Annika
AU - Gembardt, Florian
AU - Fichtner, Iduna
AU - Schultheiss, Heinz Peter
AU - Rodgers, Kathy
AU - Walther, Thomas
PY - 2009/6
Y1 - 2009/6
N2 - Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
AB - Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.
KW - Angiotensin
KW - CD34
KW - Hematopoietic stem cell
UR - http://www.scopus.com/inward/record.url?scp=66749124113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66749124113&partnerID=8YFLogxK
U2 - 10.3324/haematol.2008.000034
DO - 10.3324/haematol.2008.000034
M3 - Article
C2 - 19377080
AN - SCOPUS:66749124113
SN - 0390-6078
VL - 94
SP - 857
EP - 860
JO - Haematologica
JF - Haematologica
IS - 6
ER -