Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Silvia Heringer-Walther, Klaus Eckert, Sarah Mai Schumacher, Lutz Uharek, Annika Wulf-Goldenberg, Florian Gembardt, Iduna Fichtner, Heinz Peter Schultheiss, Kathy Rodgers, Thomas Walther

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

Original languageEnglish (US)
Pages (from-to)857-860
Number of pages4
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • Angiotensin
  • CD34
  • Hematopoietic stem cell

ASJC Scopus subject areas

  • Hematology


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