Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Silvia Heringer-Walther; Klaus Eckert; Sarah Mai Schumacher; Lutz Uharek; Annika Wulf-Goldenberg; Florian Gembardt; Iduna Fichtner; Heinz Peter Schultheiss; Kathy Rodgers; Thomas Walther

doi:10.3324/haematol.2008.000034

Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Silvia Heringer-Walther, Klaus Eckert, Sarah Mai Schumacher, Lutz Uharek, Annika Wulf-Goldenberg, Florian Gembardt, Iduna Fichtner, Heinz Peter Schultheiss, Kathy Rodgers, Thomas Walther

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34⁺ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I⁺ and CD34⁺ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

Original language	English (US)
Pages (from-to)	857-860
Number of pages	4
Journal	Haematologica
Volume	94
Issue number	6
DOIs	https://doi.org/10.3324/haematol.2008.000034
State	Published - Jun 2009
Externally published	Yes

Keywords

Angiotensin
CD34
Hematopoietic stem cell

ASJC Scopus subject areas

Hematology

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10.3324/haematol.2008.000034

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title = "Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo",

abstract = "Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.",

keywords = "Angiotensin, CD34, Hematopoietic stem cell",

author = "Silvia Heringer-Walther and Klaus Eckert and Schumacher, {Sarah Mai} and Lutz Uharek and Annika Wulf-Goldenberg and Florian Gembardt and Iduna Fichtner and Schultheiss, {Heinz Peter} and Kathy Rodgers and Thomas Walther",

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T1 - Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

AU - Heringer-Walther, Silvia

AU - Eckert, Klaus

AU - Schumacher, Sarah Mai

AU - Uharek, Lutz

AU - Wulf-Goldenberg, Annika

AU - Gembardt, Florian

AU - Fichtner, Iduna

AU - Schultheiss, Heinz Peter

AU - Rodgers, Kathy

AU - Walther, Thomas

PY - 2009/6

Y1 - 2009/6

N2 - Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

AB - Effects of angiotensin (Ang)-(1-7), an AngII metabolite, on bone marrow-derived hematopoietic cells were studied. We identified Ang-(1-7) to stimulate proliferation of human CD34+ and mononuclear cells in vitro. Under in vivo conditions, we monitored proliferation and differentiation of human cord blood mononuclear cells in NOD/SCID mice. Ang-(1-7) stimulated differentially human cells in bone marrow and accumulated them in the spleen. The number of HLA-I+ and CD34+ cells in the bone marrow was increased 42-fold and 600-fold, respectively. These results indicate a decisive impact of Ang-(1-7) on hematopoiesis and its promising therapeutic potential in diseases requiring progenitor stimulation.

KW - Angiotensin

KW - CD34

KW - Hematopoietic stem cell

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Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo

Abstract

Keywords

ASJC Scopus subject areas

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