Analysis of the Macrophage Scavenger Receptor I Gene in Swedish Hereditary and Sporadic Prostate Cancer

Fredrik Lindmark, Björn Anders Jonsson, Anders Bergh, Pär Stattin, S. Lilly Zheng, Deborah A. Meyers, Jianfeng Xu, Henrik Grönberg

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


BACKGROUND. The macrophage scavenger receptor 1 (MSR1) gene on chromosome 8p22 was recently reported as a candidate gene for hereditary prostate cancer (HPC). Here, we further elucidate the role of MSR1 in both Swedish families with HPC and in a cohort of unselected prostate cancer. METHODS. DNA samples from 83 Swedish HPC families and 215 unselected population based cases of prostate cancer as well as 425 age-matched controls were genotyped. RESULTS. A total of 18 variants were identified, including 2 exonic, 7 intronic changes, and 9 changes in the 5′- or 3′-uncoding region. Of the two exonic changes, one previously reported truncation mutation was identified, a R293X nonsense mutation. This mutation was found in 2 of the 83 (2.4%) HPC families. The R293X mutation was found more frequently in men with PC (4.9%) than in unaffected men (2.7%), consistent with previous published results, however our results were not significant (P = 0.16). To additionally test for potential association of common sequence variants and increased risk for the disease, five common polymorphisms (PRO3, INDEL1, IVS5-57, P275A, INDEL7) were genotyped in the group of 215 prostate cancer cases and 425 age-matched controls. No association between any of the five common sequence variants and prostate cancer were found. CONCLUSION. Our results suggest that mutations in MSR1 gene might play a role in prostate cancer susceptibility, particularly the R293X mutation. This study warrants further investigations of the role of MSR1 in prostate cancer etiology.

Original languageEnglish (US)
Pages (from-to)132-140
Number of pages9
Issue number2
StatePublished - May 1 2004
Externally publishedYes


  • Assciation
  • Genetic
  • Macrophage scavenger receptor 1
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Urology


Dive into the research topics of 'Analysis of the Macrophage Scavenger Receptor I Gene in Swedish Hereditary and Sporadic Prostate Cancer'. Together they form a unique fingerprint.

Cite this