Analysis of shared underlying mechanism in neurodegenerative disease

Rickeem Butler, David Bradford, Kathleen E. Rodgers

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

In this review, the relationship between bioenergetics, mitochondrial dysfunction, and inflammation will be and how they contribute to neurodegeneration, specifically in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) will be reviewed. Long-term changes in mitochondrial function, autophagy dysfunction, and immune activation are commonalities shared across these age-related disorders. Genetic risk factors for these diseases support an autophagy-immune connection in the underlying pathophysiology. Critical areas of deeper evaluation in these bioenergetic processes may lead to potential therapeutics with efficacy across multiple neurodegenerative diseases.

Original languageEnglish (US)
Article number1006089
JournalFrontiers in Aging Neuroscience
Volume14
DOIs
StatePublished - Nov 29 2022

Keywords

  • Alzheimer’s disease
  • amyotrophic lateral sclerosis
  • bioenergetics
  • immune
  • inflammation
  • metabolic
  • multiple sclerosis

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

Cite this