TY - JOUR
T1 - Analysis of prognostic features in adenocarcinoma of the cervix
AU - Kilgore, Larry C.
AU - Soong, Seng Jaw
AU - Gore, Hazel
AU - Shingleton, Hugh M.
AU - Hatch, Kenneth D.
AU - Partridge, Edward E.
N1 - Funding Information:
’ Supported in part by a grant from the National Institute of Health (CA13148). ’ To whom reprint requests should be addressed at 1016 18th Street South, Birmingham, 35205.
PY - 1988/9
Y1 - 1988/9
N2 - Uncertainties regarding the clinical behavior and management of women with primary adenocarcinoma of the cervix persist. A series of 162 patients was evaluated with emphasis on histopathology, clinical features, treatment, and survival. Sixty-seven patients underwent radical hysterectomy alone, 65 patients underwent radiation therapy alone, while the remainder were treated with combined surgery and radiotherapy. When compared to a matched series of squamous cell carcinoma patients, no statistical differences in survival could be demonstrated. Clinical stage (P < 0.001) and lesion size (P < 0.001) were the most important prognostic factors for the entire series. Patients with adenocarcinoma of varied histologic patterns were compared to patients with adenosquamous lesions and no statistical difference in survival could be demonstrated. Multivariate analysis of those women with Stage I adenocarcinoma of the cervix identified risk groups based on tumor grade, lesion size, and patient age. Patients in the low risk group had a 5-year survival of 89.5% while patients in the intermediate and high risk groups had 5-year survival rates of 68.4 and 37.3%. respectively. In patients with Stage I well-differentiated lesions survival was excellent, independent of lesion size.
AB - Uncertainties regarding the clinical behavior and management of women with primary adenocarcinoma of the cervix persist. A series of 162 patients was evaluated with emphasis on histopathology, clinical features, treatment, and survival. Sixty-seven patients underwent radical hysterectomy alone, 65 patients underwent radiation therapy alone, while the remainder were treated with combined surgery and radiotherapy. When compared to a matched series of squamous cell carcinoma patients, no statistical differences in survival could be demonstrated. Clinical stage (P < 0.001) and lesion size (P < 0.001) were the most important prognostic factors for the entire series. Patients with adenocarcinoma of varied histologic patterns were compared to patients with adenosquamous lesions and no statistical difference in survival could be demonstrated. Multivariate analysis of those women with Stage I adenocarcinoma of the cervix identified risk groups based on tumor grade, lesion size, and patient age. Patients in the low risk group had a 5-year survival of 89.5% while patients in the intermediate and high risk groups had 5-year survival rates of 68.4 and 37.3%. respectively. In patients with Stage I well-differentiated lesions survival was excellent, independent of lesion size.
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U2 - 10.1016/0090-8258(88)90281-8
DO - 10.1016/0090-8258(88)90281-8
M3 - Article
C2 - 3410344
AN - SCOPUS:0023680863
SN - 0090-8258
VL - 31
SP - 137
EP - 148
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 1
ER -