TY - JOUR
T1 - Analysis of p-chlorobenzoic acid in water by liquid chromatography-tandem mass spectrometry
AU - Vanderford, Brett J.
AU - Rosario-Ortiz, Fernando L.
AU - Snyder, Shane A.
PY - 2007/9/14
Y1 - 2007/9/14
N2 - para-Chlorobenzoic acid (p-CBA) is typically used as a probe compound to indirectly quantify hydroxyl radicals formed during advanced oxidation processes used in drinking water and wastewater treatment. A method has been developed for the sensitive analysis of p-CBA in water using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A reporting limit in water of 100 ng/L was determined for the method, which is 40-fold lower than the 4.0 μg/L reporting limit of the widely used liquid chromatography with UV detection (LC-UV) method. The method was found to be robust in difficult matrices such as wastewater and highly selective, unlike LC-UV which relies on non-specific detection at 234 nm. The detection of p-CBA below 1 μg/L during bench-scale ozonation of wastewater after hydrogen peroxide addition was demonstrated. Duplicate samples were analyzed by LC-MS/MS and LC-UV and results were found to be comparable at concentrations quantifiable by both methods.
AB - para-Chlorobenzoic acid (p-CBA) is typically used as a probe compound to indirectly quantify hydroxyl radicals formed during advanced oxidation processes used in drinking water and wastewater treatment. A method has been developed for the sensitive analysis of p-CBA in water using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A reporting limit in water of 100 ng/L was determined for the method, which is 40-fold lower than the 4.0 μg/L reporting limit of the widely used liquid chromatography with UV detection (LC-UV) method. The method was found to be robust in difficult matrices such as wastewater and highly selective, unlike LC-UV which relies on non-specific detection at 234 nm. The detection of p-CBA below 1 μg/L during bench-scale ozonation of wastewater after hydrogen peroxide addition was demonstrated. Duplicate samples were analyzed by LC-MS/MS and LC-UV and results were found to be comparable at concentrations quantifiable by both methods.
KW - LC-MS/MS
KW - Liquid chromatography
KW - Mass spectrometry
KW - p-Chlorobenzoic acid (p-CBA)
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U2 - 10.1016/j.chroma.2007.07.035
DO - 10.1016/j.chroma.2007.07.035
M3 - Article
C2 - 17689544
AN - SCOPUS:34548033995
SN - 0021-9673
VL - 1164
SP - 219
EP - 223
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - 1-2
ER -