Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

T. W. Secomb; R. Hsu; R. D. Braun; M. W. Dewhirst

Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

T. W. Secomb, R. Hsu, R. D. Braun, M. W. Dewhirst

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO₂) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO₂. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO₂, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	487-488
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - 1999
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

General Engineering

Cite this

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title = "Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation",

abstract = "A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO2, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.",

author = "Secomb, {T. W.} and R. Hsu and Braun, {R. D.} and Dewhirst, {M. W.}",

year = "1999",

language = "English (US)",

isbn = "0791816117",

volume = "42",

pages = "487--488",

booktitle = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

publisher = "ASME",

note = "1999 Bioengineering Conference ; Conference date: 16-06-1999 Through 20-06-1999",

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T1 - Analysis of oxygen transport to tumors

T2 - 1999 Bioengineering Conference

AU - Secomb, T. W.

AU - Hsu, R.

AU - Braun, R. D.

AU - Dewhirst, M. W.

PY - 1999

Y1 - 1999

N2 - A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO2, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.

AB - A theoretical model was used to study the factors that contribute to the heterogeneous distribution of tissue pressure of oxygen (PO2) and the occurrence of hypoxic regions in tumors. A Green=s function method was used to predict the distribution of PO2. For purpose of comparison, further calculations were performed in which all vessels were assumed to be at the same PO2, and in which a simple Krogh cylinder model was assumed, with the same vascular density as the simulated region. Finally, the resulting data was analyzed.

UR - http://www.scopus.com/inward/record.url?scp=0033297177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033297177&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033297177

SN - 0791816117

VL - 42

SP - 487

EP - 488

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

Y2 - 16 June 1999 through 20 June 1999

ER -

Analysis of oxygen transport to tumors: causes of heterogeneous tissue oxygenation

Abstract

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ASJC Scopus subject areas

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