TY - JOUR
T1 - Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE
AU - Keith, R. L.
AU - Gandolfi, A. J.
AU - McIntyre, L. C.
AU - Ashbaugh, M. D.
AU - Fernando, Q.
N1 - Funding Information:
The authors would like to thank Li Qiu and Richard Lind for their technical assistance and Scott Morgan for his help with manuscript preparation. This work is supported by grant P42 ES 04940 from the National Institute of Environmental Health Sciences, NIH.
PY - 1999/1/3
Y1 - 1999/1/3
N2 - This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl2, K2Cr2O7, or NaAsO2, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.
AB - This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl2, K2Cr2O7, or NaAsO2, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.
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U2 - 10.1016/S0168-583X(98)00644-2
DO - 10.1016/S0168-583X(98)00644-2
M3 - Article
AN - SCOPUS:0033518406
VL - 149
SP - 167
EP - 176
JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
SN - 0168-583X
IS - 1-2
ER -