Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE

R. L. Keith; A. J. Gandolfi; L. C. McIntyre; M. D. Ashbaugh; Q. Fernando

doi:10.1016/S0168-583X(98)00644-2

Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE

R. L. Keith, A. J. Gandolfi, L. C. McIntyre, M. D. Ashbaugh, Q. Fernando

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl₂, K₂Cr₂O₇, or NaAsO₂, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.

Original language	English (US)
Pages (from-to)	167-176
Number of pages	10
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	149
Issue number	1-2
DOIs	https://doi.org/10.1016/S0168-583X(98)00644-2
State	Published - Jan 3 1999

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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@article{176a7e6bac5441858790c51b594bbc47,

title = "Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE",

abstract = "This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl2, K2Cr2O7, or NaAsO2, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.",

author = "Keith, {R. L.} and Gandolfi, {A. J.} and McIntyre, {L. C.} and Ashbaugh, {M. D.} and Q. Fernando",

note = "Funding Information: The authors would like to thank Li Qiu and Richard Lind for their technical assistance and Scott Morgan for his help with manuscript preparation. This work is supported by grant P42 ES 04940 from the National Institute of Environmental Health Sciences, NIH.",

year = "1999",

month = jan,

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doi = "10.1016/S0168-583X(98)00644-2",

language = "English (US)",

volume = "149",

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journal = "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",

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T1 - Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE

AU - Keith, R. L.

AU - Gandolfi, A. J.

AU - McIntyre, L. C.

AU - Ashbaugh, M. D.

AU - Fernando, Q.

N1 - Funding Information: The authors would like to thank Li Qiu and Richard Lind for their technical assistance and Scott Morgan for his help with manuscript preparation. This work is supported by grant P42 ES 04940 from the National Institute of Environmental Health Sciences, NIH.

PY - 1999/1/3

Y1 - 1999/1/3

N2 - This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl2, K2Cr2O7, or NaAsO2, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.

AB - This study uses particle induced X-ray emission spectroscopy (PIXE) to examine the localization of metals in renal tissue removed from rabbits exposed to HgCl2, K2Cr2O7, or NaAsO2, or a binary combination. A small beam diameter (10 μm) and the ability to raster this beam over areas of up to 125 μm×125 μm has allowed the mapping of non-endogenous metal concentrations over the entire cross-section of the kidney. The use of step-wise sectional mapping has produced data and revealed trends in heavy metal deposition that are difficult to reproduce with other analytical methods. The combination of small beam size, high resolution, and simultaneous multi-element detection makes PIXE spectroscopy a powerful tool for investigating the impact of non-endogenous metals on the kidney.

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JO - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms

IS - 1-2

ER -

Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE

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