Analysis of Adaptive Multi-Pinhole Aperture Plates for Brain SPECT Imaging

Micaehla May, Maria Ruiz-Gonzalez, R. Garrett Richards, Michael A. King, Matthew A. Kupinski, Phillip K. Kuo, Lars R. Furenlid

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We are developing AdaptiSPECT-C, a dynamic multiple pinhole, single-photon emission computed tomography (SPECT) system dedicated to whole brain imaging whose primary purpose is to acquire data for pharmacokinetic analysis. We have designed prototype hardware, control electronics and software that create adjustable pinhole apertures for this clinical SPECT system. The design enables us to dynamically move between imaging configurations corresponding to a variety of desired resolutions and sensitivities. Preliminary testing is necessary to evaluate the aperture assembly performance and reliability. Modular aperture plates are designed to provide multiple choices for the trade-offs between resolution and sensitivity, in order to improve pharmacokinetic SPECT imaging. Each camera is outfitted with 5 adaptive pinholes that can be adjusted to different diameters. These apertures are designed to respond to evolving biodistributions of radiotracers. We present the results of testing the operation of the aperture plate system. We captured projections from a variety pinhole imaging configurations with a point source object.

Original languageEnglish (US)
Title of host publication2022 IEEE NSS/MIC RTSD - IEEE Nuclear Science Symposium, Medical Imaging Conference and Room Temperature Semiconductor Detector Conference
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781665488723
DOIs
StatePublished - 2022
Event2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022 - Milano, Italy
Duration: Nov 5 2022Nov 12 2022

Publication series

Name2022 IEEE NSS/MIC RTSD - IEEE Nuclear Science Symposium, Medical Imaging Conference and Room Temperature Semiconductor Detector Conference

Conference

Conference2022 IEEE Nuclear Science Symposium, Medical Imaging Conference, and Room Temperature Semiconductor Detector Conference, IEEE NSS MIC RTSD 2022
Country/TerritoryItaly
CityMilano
Period11/5/2211/12/22

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Radiology Nuclear Medicine and imaging
  • Instrumentation
  • Nuclear and High Energy Physics

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