Analog CMOS design for optical coherence tomography signal detection and processing

Wei Xu; David L. Mathine; Jennifer K. Barton

doi:10.1109/TBME.2007.905402

Analog CMOS design for optical coherence tomography signal detection and processing

Wei Xu
, David L. Mathine
, Jennifer K. Barton

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A CMOS circuit was designed and fabricated for optical coherence tomography (OCT) signal detection and processing. The circuit includes a photoreceiver, differential gain stage and lock-in amplifier based demodulator. The photoreceiver consists of a CMOS photodetector and low noise differential transimpedance amplifier which converts the optical interference signal into a voltage. The differential gain stage further amplifies the signal. The in-phase and quadrature channels of the lock-in amplifier each include an analog mixer and switched-capacitor low-pass filter with an external mixer reference signal. The interferogram envelope and phase can be extracted with this configuration, enabling Doppler OCT measurements. A sensitivity of -80 dB is achieved with faithful reproduction of the interferometric signal envelope. A sample image of finger tip is presented.

Original language	English (US)
Pages (from-to)	485-489
Number of pages	5
Journal	IEEE Transactions on Biomedical Engineering
Volume	55
Issue number	2
DOIs	https://doi.org/10.1109/TBME.2007.905402
State	Published - Feb 2008

Keywords

Biomedical imaging
CMOS analog integrated circuits
Optical tomography

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2007.905402

Cite this

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title = "Analog CMOS design for optical coherence tomography signal detection and processing",

abstract = "A CMOS circuit was designed and fabricated for optical coherence tomography (OCT) signal detection and processing. The circuit includes a photoreceiver, differential gain stage and lock-in amplifier based demodulator. The photoreceiver consists of a CMOS photodetector and low noise differential transimpedance amplifier which converts the optical interference signal into a voltage. The differential gain stage further amplifies the signal. The in-phase and quadrature channels of the lock-in amplifier each include an analog mixer and switched-capacitor low-pass filter with an external mixer reference signal. The interferogram envelope and phase can be extracted with this configuration, enabling Doppler OCT measurements. A sensitivity of -80 dB is achieved with faithful reproduction of the interferometric signal envelope. A sample image of finger tip is presented.",

keywords = "Biomedical imaging, CMOS analog integrated circuits, Optical tomography",

author = "Wei Xu and Mathine, \{David L.\} and Barton, \{Jennifer K.\}",

note = "Funding Information: Manuscript received July 12, 2006; revised May 28, 2007. This work was supported in part by the National Institutes of Health under Grant R01 EB001032. Asterisk indicates corresponding author.",

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doi = "10.1109/TBME.2007.905402",

language = "English (US)",

volume = "55",

pages = "485--489",

journal = "IEEE Transactions on Biomedical Engineering",

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T1 - Analog CMOS design for optical coherence tomography signal detection and processing

AU - Xu, Wei

AU - Mathine, David L.

AU - Barton, Jennifer K.

N1 - Funding Information: Manuscript received July 12, 2006; revised May 28, 2007. This work was supported in part by the National Institutes of Health under Grant R01 EB001032. Asterisk indicates corresponding author.

PY - 2008/2

Y1 - 2008/2

N2 - A CMOS circuit was designed and fabricated for optical coherence tomography (OCT) signal detection and processing. The circuit includes a photoreceiver, differential gain stage and lock-in amplifier based demodulator. The photoreceiver consists of a CMOS photodetector and low noise differential transimpedance amplifier which converts the optical interference signal into a voltage. The differential gain stage further amplifies the signal. The in-phase and quadrature channels of the lock-in amplifier each include an analog mixer and switched-capacitor low-pass filter with an external mixer reference signal. The interferogram envelope and phase can be extracted with this configuration, enabling Doppler OCT measurements. A sensitivity of -80 dB is achieved with faithful reproduction of the interferometric signal envelope. A sample image of finger tip is presented.

AB - A CMOS circuit was designed and fabricated for optical coherence tomography (OCT) signal detection and processing. The circuit includes a photoreceiver, differential gain stage and lock-in amplifier based demodulator. The photoreceiver consists of a CMOS photodetector and low noise differential transimpedance amplifier which converts the optical interference signal into a voltage. The differential gain stage further amplifies the signal. The in-phase and quadrature channels of the lock-in amplifier each include an analog mixer and switched-capacitor low-pass filter with an external mixer reference signal. The interferogram envelope and phase can be extracted with this configuration, enabling Doppler OCT measurements. A sensitivity of -80 dB is achieved with faithful reproduction of the interferometric signal envelope. A sample image of finger tip is presented.

KW - Biomedical imaging

KW - CMOS analog integrated circuits

KW - Optical tomography

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JO - IEEE Transactions on Biomedical Engineering

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Analog CMOS design for optical coherence tomography signal detection and processing

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