An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules

Linan Jiang; Karl P. Gerhardt; Brian Myer; Yitshak Zohar; Stanley Pau

doi:10.1109/MEMSYS.2008.4443628

An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules

Linan Jiang, Karl P. Gerhardt, Brian Myer, Yitshak Zohar, Stanley Pau

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

A 30mm-long multimode waveguide, 40μm wide and 40μm high, is fabricated on a silicon wafer using polymer SU-8 as the core and liquid buffer as the cladding. Antibodies are successfully immobilized on the SU-8 surface designated for binding target antigens dispersed in the buffer solution. Evanescent-wave spectroscopy is performed by exciting the fluorescently-labeled antigens, bound to the waveguide surface within its evanescence field, and measuring emission light intensity. This evanescent-wave biosensor detects specific molecular interaction; its output depends on antigen concentration with a sensitivity of 40 light counts per 1μg/ml.

Original language	English (US)
Title of host publication	MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems
Pages	204-207
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2008.4443628
State	Published - 2008
Event	21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson - Tucson, AZ, United States Duration: Jan 13 2008 → Jan 17 2008

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson
Country/Territory	United States
City	Tucson, AZ
Period	1/13/08 → 1/17/08

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2008.4443628

Cite this

Jiang, L., Gerhardt, K. P., Myer, B., Zohar, Y., & Pau, S. (2008). An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules. In MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems (pp. 204-207). Article 4443628 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2008.4443628

An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules. / Jiang, Linan; Gerhardt, Karl P.; Myer, Brian et al.
MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems. 2008. p. 204-207 4443628 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jiang, L, Gerhardt, KP, Myer, B, Zohar, Y & Pau, S 2008, An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules. in MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems., 4443628, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 204-207, 21st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2008 Tucson, Tucson, AZ, United States, 1/13/08. https://doi.org/10.1109/MEMSYS.2008.4443628

Jiang L, Gerhardt KP, Myer B, Zohar Y , Pau S. An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules. In MEMS 2008 Tucson - 21st IEEE International Conference on Micro Electro Mechanical Systems. 2008. p. 204-207. 4443628. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2008.4443628

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abstract = "A 30mm-long multimode waveguide, 40μm wide and 40μm high, is fabricated on a silicon wafer using polymer SU-8 as the core and liquid buffer as the cladding. Antibodies are successfully immobilized on the SU-8 surface designated for binding target antigens dispersed in the buffer solution. Evanescent-wave spectroscopy is performed by exciting the fluorescently-labeled antigens, bound to the waveguide surface within its evanescence field, and measuring emission light intensity. This evanescent-wave biosensor detects specific molecular interaction; its output depends on antigen concentration with a sensitivity of 40 light counts per 1μg/ml.",

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AB - A 30mm-long multimode waveguide, 40μm wide and 40μm high, is fabricated on a silicon wafer using polymer SU-8 as the core and liquid buffer as the cladding. Antibodies are successfully immobilized on the SU-8 surface designated for binding target antigens dispersed in the buffer solution. Evanescent-wave spectroscopy is performed by exciting the fluorescently-labeled antigens, bound to the waveguide surface within its evanescence field, and measuring emission light intensity. This evanescent-wave biosensor detects specific molecular interaction; its output depends on antigen concentration with a sensitivity of 40 light counts per 1μg/ml.

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An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules

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