An integrative approach to the control of cancer pain

Patrick W. Mantyh; Tony L. Yaksh

doi:10.1093/acprof:oso/9780198515616.003.0015

An integrative approach to the control of cancer pain

Patrick W. Mantyh
, Tony L. Yaksh

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This chapter discusses how cancer pain is generated and how the sensory information it initiates is processed as it moves from sense organ to the cerebral cortex under a constantly changing molecular architecture. Topics covered include primary afferent sensory neurons, tumour properties that excite nociceptors, tumour-induced release of protons and acidosis, tumor-induced distension and destruction of sensory fibers, and central sensitization in cancer pain.

Original language	English (US)
Title of host publication	The Neurobiology of Pain
Subtitle of host publication	(Molecular and Cellular Neurobiology)
Publisher	Oxford University Press
ISBN (Electronic)	9780191723650
ISBN (Print)	9780198515616
DOIs	https://doi.org/10.1093/acprof:oso/9780198515616.003.0015
State	Published - Jan 1 2010

Keywords

Cancer pain
Nociceptors
Tumor cells

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1093/acprof:oso/9780198515616.003.0015

Cite this

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KW - Nociceptors

KW - Tumor cells

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An integrative approach to the control of cancer pain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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