An integrative approach to the control of cancer pain

Patrick W. Mantyh, Tony L. Yaksh

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses how cancer pain is generated and how the sensory information it initiates is processed as it moves from sense organ to the cerebral cortex under a constantly changing molecular architecture. Topics covered include primary afferent sensory neurons, tumour properties that excite nociceptors, tumour-induced release of protons and acidosis, tumor-induced distension and destruction of sensory fibers, and central sensitization in cancer pain.

Original languageEnglish (US)
Title of host publicationThe Neurobiology of Pain
Subtitle of host publication(Molecular and Cellular Neurobiology)
PublisherOxford University Press
ISBN (Electronic)9780191723650
ISBN (Print)9780198515616
StatePublished - Jan 1 2010


  • Cancer pain
  • Nociceptors
  • Tumor cells

ASJC Scopus subject areas

  • Neuroscience(all)


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