An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells

M. Junkin; Y. Lu; P. Deymier; P. K. Wong

doi:10.1109/MEMSYS.2011.5734569

An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells

M. Junkin, Y. Lu, P. Deymier, P. K. Wong

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Dynamic signal conduction in endothelial networks plays an important role in endothelial function, and characteristics of the network architecture itself are theorized to play a role in this function. We have therefore developed an integrated mechanostimulation system to create spatiotemporal stimuli including geometric cues, fluidic shear, mechanical deformation, and tunable surface stiffness for probing intercellular communication in artificial networks of human umbilical vein endothelial (HUVEC) cells. The system enables detection of architecture dependent (e.g. linear, grid, and branching patterns), spatiotemporal calcium propagation characteristics such as speed, contact length, and repeated stimulation dependence due to mechanostimulation at the single cell level.

Original language	English (US)
Title of host publication	2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011
Pages	893-896
Number of pages	4
DOIs	https://doi.org/10.1109/MEMSYS.2011.5734569
State	Published - 2011
Event	24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011 - Cancun, Mexico Duration: Jan 23 2011 → Jan 27 2011

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011
Country/Territory	Mexico
City	Cancun
Period	1/23/11 → 1/27/11

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2011.5734569

Cite this

Junkin, M., Lu, Y., Deymier, P., & Wong, P. K. (2011). An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells. In 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011 (pp. 893-896). Article 5734569 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2011.5734569

An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells. / Junkin, M.; Lu, Y.; Deymier, P. et al.
2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011. 2011. p. 893-896 5734569 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Junkin, M, Lu, Y, Deymier, P & Wong, PK 2011, An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells. in 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011., 5734569, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 893-896, 24th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2011, Cancun, Mexico, 1/23/11. https://doi.org/10.1109/MEMSYS.2011.5734569

Junkin M, Lu Y, Deymier P , Wong PK. An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells. In 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems, MEMS 2011. 2011. p. 893-896. 5734569. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2011.5734569

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An integrated mechanostimulation system for probing architecture based calcium signaling in HUVEC cells

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