TY - JOUR
T1 - An integrated health risk assessment of indigenous children exposed to arsenic in Sonora, Mexico
AU - Maldonado Escalante, Juan Francisco
AU - Meza Figueroa, Diana
AU - Dévora Figueroa, Ana Gabriela
AU - García Rico, Leticia
AU - Burgess, Jefferey L.
AU - Lantz, R. Clark
AU - Yañez Estrada, Leticia
AU - Martínez Cinco, Marco Antonio
AU - Balderas Cortés, José de Jesús
AU - Mondaca Fernández, Iram
AU - Meza Montenegro, María Mercedes
N1 - Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Exposure to inorganic arsenic (InAs) through drinking water, even at low to moderate concentrations, is a global public health problem. The objectives of this study were to estimate the risk ratio (HQ), cancer risk (R), and DNA damage (comet assay) of children from three indigenous Yaqui populations located in southern Sonora, Mexico, who were exposed to InAs through drinking water. A cross-sectional study was employed, and analysis of InAs in water and urine was performed via HPLC/ICP-MS. InAs levels in drinking water from Pótam, Vícam, and Cócorit were 108.2, 36.0, and 6.2 μg/L−1 respectively. Children from Pótam had arsenic concentrations in urine of 107.1 μg As L−1 compared with 40.3 μg As L−1 for the children of Cócorit. The HQ values for the children of Pótam, Vícam, and Cócorit were 16.64, 6.02, and 0.94, while the R values were 9.4E-04, 3.5E-04, and 5.7E-05, respectively. Children with the highest arsenic exposure had significantly increased DNA damage (OTM = 14.4 vs. 4.3) [p < 0.0005] which positively correlated with urinary arsenic levels (r = 0.56, p < 0.0001). In conclusion, children of Pótam and Vícam are at significant risk of developing chronic diseases and cancers associated with chronic exposure to this metalloid.
AB - Exposure to inorganic arsenic (InAs) through drinking water, even at low to moderate concentrations, is a global public health problem. The objectives of this study were to estimate the risk ratio (HQ), cancer risk (R), and DNA damage (comet assay) of children from three indigenous Yaqui populations located in southern Sonora, Mexico, who were exposed to InAs through drinking water. A cross-sectional study was employed, and analysis of InAs in water and urine was performed via HPLC/ICP-MS. InAs levels in drinking water from Pótam, Vícam, and Cócorit were 108.2, 36.0, and 6.2 μg/L−1 respectively. Children from Pótam had arsenic concentrations in urine of 107.1 μg As L−1 compared with 40.3 μg As L−1 for the children of Cócorit. The HQ values for the children of Pótam, Vícam, and Cócorit were 16.64, 6.02, and 0.94, while the R values were 9.4E-04, 3.5E-04, and 5.7E-05, respectively. Children with the highest arsenic exposure had significantly increased DNA damage (OTM = 14.4 vs. 4.3) [p < 0.0005] which positively correlated with urinary arsenic levels (r = 0.56, p < 0.0001). In conclusion, children of Pótam and Vícam are at significant risk of developing chronic diseases and cancers associated with chronic exposure to this metalloid.
KW - DNA damage
KW - arsenic
KW - cancer risk
KW - health risk
KW - urine
KW - water
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U2 - 10.1080/10807039.2018.1449098
DO - 10.1080/10807039.2018.1449098
M3 - Article
AN - SCOPUS:85044533889
SN - 1080-7039
VL - 25
SP - 706
EP - 721
JO - Human and Ecological Risk Assessment
JF - Human and Ecological Risk Assessment
IS - 3
ER -