Abstract
Efforts to map the human protein interactome have resulted in information about thousands of multi-protein assemblies housed in public repositories, but the molecular characterization and stoichiometry of their protein subunits remains largely unknown. Here, we report a computational search strategy that supports hierarchical top-down analysis for precise identification and scoring of multi-proteoform complexes by native mass spectrometry.
Original language | English (US) |
---|---|
Pages (from-to) | 237-240 |
Number of pages | 4 |
Journal | Nature Methods |
Volume | 13 |
Issue number | 3 |
DOIs | |
State | Published - Feb 25 2016 |
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Cell Biology