An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

Keyphrases

• TP53 mutation 100%
• Loss Function 100%
• Distinct Roles 100%
• Skin Cancer 100%
• Gain-of-function mutation 100%
• Inducible Mouse Model 100%
• Tumor 75%
• Skin Tumor 50%
• Tumor Formation 50%
• Gain-of-function 50%
• Aneuploidy 25%
• Metastasis 25%
• Effective Therapy 25%
• Tumor Progression 25%
• Poor Prognosis 25%
• Non-melanoma Skin Cancer 25%
• P53 Gene 25%
• Skin Carcinogenesis 25%
• Tumor Induction 25%
• KRAS G12C 25%
• Centrosome Amplification 25%
• Function Properties 25%
• Oncogenic Properties 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Mouse Model 100%
• Protein P53 100%
• Skin Cancer 100%
• Neoplasm 23%
• Carcinogenesis 23%
• Skin Tumor 15%
• Tumor Growth 7%
• Aneuploidy 7%
• Skin Carcinogenesis 7%
• Non Melanoma Skin Cancer 7%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Mouse Model 100%
• Carcinogenesis 33%
• Gain of Function Mutation 25%
• Allele 16%
• Centrosome 8%
• Aneuploidy 8%
• Tumor Progression 8%
• Protein P53 8%
• Loss of Function Mutation 8%