An in vitro approach to the study of target organ toxicity of drugs and chemicals

Daniel Acosta; Elsie M.B. Sorensen; David C. Anuforo; David B. Mitchell; Kenneth Ramos; Kenneth S. Santone; Mary Ann Smith

doi:10.1007/BF02620841

An in vitro approach to the study of target organ toxicity of drugs and chemicals

Daniel Acosta, Elsie M.B. Sorensen, David C. Anuforo, David B. Mitchell, Kenneth Ramos, Kenneth S. Santone, Mary Ann Smith

Medicine

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems. The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro cellular systems.

Original language	English (US)
Pages (from-to)	495-504
Number of pages	10
Journal	In Vitro Cellular & Developmental Biology
Volume	21
Issue number	9
DOIs	https://doi.org/10.1007/BF02620841
State	Published - Sep 1985

Keywords

in vitro
target organ
toxicity

ASJC Scopus subject areas

Biotechnology
Plant Science

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10.1007/BF02620841

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abstract = "A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems. The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro cellular systems.",

keywords = "in vitro, target organ, toxicity",

author = "Daniel Acosta and Sorensen, {Elsie M.B.} and Anuforo, {David C.} and Mitchell, {David B.} and Kenneth Ramos and Santone, {Kenneth S.} and Smith, {Mary Ann}",

year = "1985",

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AU - Ramos, Kenneth

AU - Santone, Kenneth S.

AU - Smith, Mary Ann

PY - 1985/9

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AB - A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems. The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro cellular systems.

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An in vitro approach to the study of target organ toxicity of drugs and chemicals

Abstract

Keywords

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