An in vitro approach to the study of target organ toxicity of drugs and chemicals

Daniel Acosta, Elsie M.B. Sorensen, David C. Anuforo, David B. Mitchell, Kenneth Ramos, Kenneth S. Santone, Mary Ann Smith

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


A major goal of our laboratory has been the development of primary culture systems that retain differentiated fucntions and responses characteristic of intact tissues in vivo. Specifically, we have developed cellular models of primary cultures of rat heart, liver, and kidney cells to explore the mechanisms by which drugs or chemicals may be toxic to key organs of the body and to develop new techniques by which xenobiotics may be evaluated or identified as potential toxicants to living systems. The purpose of this paper is to describe our rationale and approach to the study of target organ toxicology with in vitro cellular systems.

Original languageEnglish (US)
Pages (from-to)495-504
Number of pages10
JournalIn Vitro Cellular & Developmental Biology
Issue number9
StatePublished - Sep 1985


  • in vitro
  • target organ
  • toxicity

ASJC Scopus subject areas

  • Biotechnology
  • Plant Science


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