Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.
|Original language||English (US)|
|Journal||Acta Crystallographica Section E: Structure Reports Online|
|State||Published - Dec 2003|
ASJC Scopus subject areas
- Materials Science(all)
- Condensed Matter Physics