An ethanol solvate of beclomethasone dipropionate

Philip J. Kuehl; Michael D. Carducci; Paul B. Myrdal

doi:10.1107/S1600536803024425

An ethanol solvate of beclomethasone dipropionate

Philip J. Kuehl, Michael D. Carducci, Paul B. Myrdal

Pharmacy Practice and Science

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Abstract

Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C ₂₈H₃₇ClO₇·2C₂H₆O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

Original language	English (US)
Pages (from-to)	o1888-o1890
Journal	Acta Crystallographica Section E: Structure Reports Online
Volume	59
Issue number	12
DOIs	https://doi.org/10.1107/S1600536803024425
State	Published - Dec 2003

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

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10.1107/S1600536803024425

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abstract = "Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.",

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year = "2003",

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T1 - An ethanol solvate of beclomethasone dipropionate

AU - Kuehl, Philip J.

AU - Carducci, Michael D.

AU - Myrdal, Paul B.

PY - 2003/12

Y1 - 2003/12

N2 - Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

AB - Beclomethasone dipropionate (BDP) is a widely used corticosteroid formulated in metered dose inhalers (MDI) for the treatment of asthma. The crystal structure of a BDP ethanol solvate of apparent formula C 28H37ClO7·2C2H6O has been determined at 170 K. The crystal investigated in this study was grown in a 3% (w/w) saturated solution of 200-proof ethanol (EtOH) at 203 K. Under these conditions, BDP crystallizes with a channel structure that allows for the inclusion of disordered ethanol molecules. The steroid molecules are held in place through intermolecular hydrogen bonding and chlorine-chlorine interactions.

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JF - Acta Crystallographica Section E: Structure Reports Online

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An ethanol solvate of beclomethasone dipropionate

Abstract

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CCDC 227863: Experimental Crystal Structure Determination

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An ethanol solvate of beclomethasone dipropionate

Abstract

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Datasets

CCDC 227863: Experimental Crystal Structure Determination

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