An enhancer responsible for activating transcription at the midblastula transition in Xenopus development

P. A. Krieg; D. A. Melton

doi:10.1073/pnas.84.8.2331

An enhancer responsible for activating transcription at the midblastula transition in Xenopus development

P. A. Krieg, D. A. Melton

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-β-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.

Original language	English (US)
Pages (from-to)	2331-2335
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	84
Issue number	8
DOIs	https://doi.org/10.1073/pnas.84.8.2331
State	Published - 1987

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.84.8.2331

Cite this

@article{aef69e80edf545038f535cc91382a382,

title = "An enhancer responsible for activating transcription at the midblastula transition in Xenopus development",

abstract = "Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-β-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.",

author = "Krieg, \{P. A.\} and Melton, \{D. A.\}",

year = "1987",

doi = "10.1073/pnas.84.8.2331",

language = "English (US)",

volume = "84",

pages = "2331--2335",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "8",

}

TY - JOUR

T1 - An enhancer responsible for activating transcription at the midblastula transition in Xenopus development

AU - Krieg, P. A.

AU - Melton, D. A.

PY - 1987

Y1 - 1987

N2 - Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-β-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.

AB - Transcripts from the Xenopus gene GS17 are absent from oocytes and first appear at the midblastula transition (MBT), about 8 hr after fertilization. Injection experiments with deletions of the GS17 gene and GS17-β-globin hybrid genes show that a relatively short sequence of 74 base pairs is sufficient to activate, in cis, transcription at the MBT. This 74-base sequence is located about 700 bases upstream of the GS17 promoter and has the properties of an enhancer element.

UR - https://www.scopus.com/pages/publications/0023236431

UR - https://www.scopus.com/inward/citedby.url?scp=0023236431&partnerID=8YFLogxK

U2 - 10.1073/pnas.84.8.2331

DO - 10.1073/pnas.84.8.2331

M3 - Article

C2 - 3470796

AN - SCOPUS:0023236431

SN - 0027-8424

VL - 84

SP - 2331

EP - 2335

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 8

ER -

An enhancer responsible for activating transcription at the midblastula transition in Xenopus development

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this