An enantioselective synthesis of (+)-(S)-[n]-gingerols via the l-proline-catalyzed aldol reaction

Shichao Ma; Shilei Zhang; Wenhu Duan; Wei Wang

doi:10.1016/j.bmcl.2009.03.081

An enantioselective synthesis of (+)-(S)-[n]-gingerols via the l-proline-catalyzed aldol reaction

Shichao Ma, Shilei Zhang, Wenhu Duan, Wei Wang

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.

Original language	English (US)
Pages (from-to)	3909-3911
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2009.03.081
State	Published - Jul 15 2009
Externally published	Yes

Keywords

Cross aldol
Gingerols
Organocatalysis
Proline

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.03.081

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abstract = "An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.",

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AU - Ma, Shichao

AU - Zhang, Shilei

AU - Duan, Wenhu

AU - Wang, Wei

PY - 2009/7/15

Y1 - 2009/7/15

N2 - An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.

AB - An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.

KW - Cross aldol

KW - Gingerols

KW - Organocatalysis

KW - Proline

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ER -

An enantioselective synthesis of (+)-(S)-[n]-gingerols via the l-proline-catalyzed aldol reaction

Abstract

Keywords

ASJC Scopus subject areas

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