An enantioselective synthesis of (+)-(S)-[n]-gingerols via the l-proline-catalyzed aldol reaction

Shichao Ma, Shilei Zhang, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

An enantioselective approach to (+)-(S)-[n]-gingerols (1a-c) has been developed. The requisite stereogenic centers of target molecules are facilely constructed by the proline-catalyzed cross-aldol reaction from readily available achiral starting materials.

Original languageEnglish (US)
Pages (from-to)3909-3911
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number14
DOIs
StatePublished - Jul 15 2009
Externally publishedYes

Keywords

  • Cross aldol
  • Gingerols
  • Organocatalysis
  • Proline

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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