An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

Shilei Zhang, Xiaobei Chen, Jiangang Zhang, Wei Wang, Wenhu Duan

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.

Original languageEnglish (US)
Pages (from-to)383-386
Number of pages4
JournalSynthesis
Issue number3
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Keywords

  • Aldehyde
  • Aldol reaction
  • Ketone
  • Lipoic acid
  • Proline

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction'. Together they form a unique fingerprint.

Cite this