Abstract
An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 383-386 |
| Number of pages | 4 |
| Journal | Synthesis |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 1 2008 |
| Externally published | Yes |
Keywords
- Aldehyde
- Aldol reaction
- Ketone
- Lipoic acid
- Proline
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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