An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

Shilei Zhang; Xiaobei Chen; Jiangang Zhang; Wei Wang; Wenhu Duan

doi:10.1055/s-2008-1032022

An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

Shilei Zhang, Xiaobei Chen, Jiangang Zhang, Wei Wang, Wenhu Duan

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.

Original language	English (US)
Pages (from-to)	383-386
Number of pages	4
Journal	Synthesis
Issue number	3
DOIs	https://doi.org/10.1055/s-2008-1032022
State	Published - Feb 1 2008
Externally published	Yes

Keywords

Aldehyde
Aldol reaction
Ketone
Lipoic acid
Proline

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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10.1055/s-2008-1032022

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title = "An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction",

abstract = "An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.",

keywords = "Aldehyde, Aldol reaction, Ketone, Lipoic acid, Proline",

author = "Shilei Zhang and Xiaobei Chen and Jiangang Zhang and Wei Wang and Wenhu Duan",

year = "2008",

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day = "1",

doi = "10.1055/s-2008-1032022",

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journal = "Synthesis",

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T1 - An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

AU - Zhang, Shilei

AU - Chen, Xiaobei

AU - Zhang, Jiangang

AU - Wang, Wei

AU - Duan, Wenhu

PY - 2008/2/1

Y1 - 2008/2/1

N2 - An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.

AB - An efficient, highly stereocontrolled formal synthesis of (+)-(R)-α-lipoic acid was achieved, which utilizes an L-proline-catalyzed highly enantio- and diastereoselective cross-aldol reaction as the key step.

KW - Aldehyde

KW - Aldol reaction

KW - Ketone

KW - Lipoic acid

KW - Proline

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U2 - 10.1055/s-2008-1032022

DO - 10.1055/s-2008-1032022

M3 - Article

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JF - Synthesis

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ER -

An enantioselective formal synthesis of (+)-(R)-α-lipoic acid by an L-proline-catalyzed aldol reaction

Abstract

Keywords

ASJC Scopus subject areas

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