Abstract
An efficient method of preparing various terminal alkynes from 1,1-dibromo-1-alkenes by using TBAF (tetra-n-butylammonium fluoride) as a base and triphenylphosphane as a reductant was developed. This method is strong base and low/high temperatures free, and can tolerate a broad range of substrates. These advantages were well demonstrated by the application of this method to the total synthesis of polyene natural product dihydroxerulin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 553-560 |
| Number of pages | 8 |
| Journal | Advanced Synthesis and Catalysis |
| Volume | 357 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 9 2015 |
| Externally published | Yes |
Keywords
- 1,1-dibromo-1-alkenes
- Dihydroxerulin
- Terminal alkynes
- Tetra-n-butylammonium fluoride
- Triphenylphosphane
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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