An atlas of nano-enabled neural interfaces

Héctor Acarón Ledesma, Xiaojian Li, João L. Carvalho-de-Souza, Wei Wei, Francisco Bezanilla, Bozhi Tian

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Advances in microscopy and molecular strategies have allowed researchers to gain insight into the intricate organization of the mammalian brain and the roles that neurons play in processing information. Despite vast progress, therapeutic strategies for neurological disorders remain limited, owing to a lack of biomaterials for sensing and modulating neuronal signalling in vivo. Therefore, there is a pressing need for developing material-based tools that can form seamless biointerfaces and interrogate the brain with unprecedented resolution. In this Review, we discuss important considerations in material design and implementation, highlight recent breakthroughs in neural sensing and modulation, and propose future directions in neurotechnology research. Our goal is to create an atlas for nano-enabled neural interfaces and to demonstrate how emerging nanotechnologies can interrogate neural systems spanning multiple biological length scales.

Original languageEnglish (US)
Pages (from-to)645-657
Number of pages13
JournalNature Nanotechnology
Issue number7
StatePublished - Jul 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering


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