An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone

Xianwen Gan; Wei Jiang; Wei Wang; Lihong Hu

doi:10.1021/ol802645f

An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone

Xianwen Gan
, Wei Jiang
, Wei Wang
, Lihong Hu

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

(Chemical Equation Presented) Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner. The method serves as a key step in the total synthesis of leucomelone in three steps and in 61% overall yield.

Original language	English (US)
Pages (from-to)	589-592
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1021/ol802645f
State	Published - Feb 5 2009
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol802645f

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abstract = "(Chemical Equation Presented) Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner. The method serves as a key step in the total synthesis of leucomelone in three steps and in 61\% overall yield.",

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AU - Wang, Wei

AU - Hu, Lihong

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AB - (Chemical Equation Presented) Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner. The method serves as a key step in the total synthesis of leucomelone in three steps and in 61% overall yield.

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An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone

Abstract

ASJC Scopus subject areas

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