An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone

Xianwen Gan, Wei Jiang, Wei Wang, Lihong Hu

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

(Chemical Equation Presented) Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner. The method serves as a key step in the total synthesis of leucomelone in three steps and in 61% overall yield.

Original languageEnglish (US)
Pages (from-to)589-592
Number of pages4
JournalOrganic Letters
Volume11
Issue number3
DOIs
StatePublished - Feb 5 2009
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. Three-step synthesis of leucomelone'. Together they form a unique fingerprint.

Cite this