An "aND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

Wenli Wang, Junwei Chen, Huijuan Ma, Wanjin Xing, Nan Lv, Baoning Zhang, Huan Xu, Wei Wang, Kaiyan Lou

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.

Original languageEnglish (US)
Pages (from-to)8166-8169
Number of pages4
JournalChemical Communications
Volume57
Issue number66
DOIs
StatePublished - Aug 25 2021
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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