An "aND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

Wenli Wang; Junwei Chen; Huijuan Ma; Wanjin Xing; Nan Lv; Baoning Zhang; Huan Xu; Wei Wang; Kaiyan Lou

doi:10.1039/d1cc01859k

An "aND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

Wenli Wang, Junwei Chen, Huijuan Ma, Wanjin Xing, Nan Lv, Baoning Zhang, Huan Xu, Wei Wang, Kaiyan Lou

Pharmacology and Toxicology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.

Original language	English (US)
Pages (from-to)	8166-8169
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	66
DOIs	https://doi.org/10.1039/d1cc01859k
State	Published - Aug 25 2021

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d1cc01859k

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abstract = "An {"}AND{"}-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.",

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T1 - An "aND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

AU - Wang, Wenli

AU - Chen, Junwei

AU - Ma, Huijuan

AU - Xing, Wanjin

AU - Lv, Nan

AU - Zhang, Baoning

AU - Xu, Huan

AU - Wang, Wei

AU - Lou, Kaiyan

PY - 2021/8/25

Y1 - 2021/8/25

N2 - An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.

AB - An "AND"-logic-gate-based fluorescent probe NAP-DCP-4 with dual reactive sites is reported, which has improved selectivity for methylglyoxal over glyoxal, featuring formaldehyde-enhanced methylglyoxal detection and irreversible and reversible turn-on fluorescence responses at different excitation wavelengths. Its cell-impermeability enables facile monitoring of extracellular methylglyoxal level changes in the supernatant of activated macrophages.

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EP - 8169

JO - Chemical Communications

JF - Chemical Communications

IS - 66

ER -

An "aND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages

Abstract

ASJC Scopus subject areas

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