An amine sulfonamide organocatalyst for promoting direct, highly enantioselective α-aminoxylation reactions of aldehydes and ketones

Wei Wang, Jian Wang, Hao Li, Lixin Liao

Research output: Contribution to journalArticlepeer-review

100 Scopus citations

Abstract

A novel, pyrrolidine sulfonamide-based organocatalyst has been developed and used to catalyze direct, efficient and α-aminoxylation reactions of aldehydes and ketones with excellent regio- and enantioselectivities. Unlike l-proline, the new catalyst exhibits high activity and enantioselectivity when used in a variety of organic solvents.

Original languageEnglish (US)
Pages (from-to)7235-7238
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number39
DOIs
StatePublished - Sep 20 2004
Externally publishedYes

Keywords

  • Aldehydes
  • Asymmetric catalysis
  • Ketones
  • Pyrrolidine sulfonamide
  • α-Aminoxylation

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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