An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

Byunghee Yoo; Vipul R. Sheth; Mark D. Pagel

doi:10.1016/j.tetlet.2009.05.061

An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

Byunghee Yoo, Vipul R. Sheth, Mark D. Pagel

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

Original language	English (US)
Pages (from-to)	4459-4462
Number of pages	4
Journal	Tetrahedron Letters
Volume	50
Issue number	31
DOIs	https://doi.org/10.1016/j.tetlet.2009.05.061
State	Published - Aug 5 2009

Keywords

DOTA
Fmoc
MRI
Molecular Imaging
PARACEST
SPPS

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.05.061

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title = "An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis",

abstract = "An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.",

keywords = "DOTA, Fmoc, MRI, Molecular Imaging, PARACEST, SPPS",

author = "Byunghee Yoo and Sheth, {Vipul R.} and Pagel, {Mark D.}",

note = "Funding Information: This work was supported by the National Cancer Institute through NIH Grant R21 CA133455-01. ",

year = "2009",

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T1 - An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

AU - Yoo, Byunghee

AU - Sheth, Vipul R.

AU - Pagel, Mark D.

N1 - Funding Information: This work was supported by the National Cancer Institute through NIH Grant R21 CA133455-01.

PY - 2009/8/5

Y1 - 2009/8/5

N2 - An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

AB - An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional solid phase peptide synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

KW - DOTA

KW - Fmoc

KW - MRI

KW - Molecular Imaging

KW - PARACEST

KW - SPPS

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U2 - 10.1016/j.tetlet.2009.05.061

DO - 10.1016/j.tetlet.2009.05.061

M3 - Article

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SN - 0040-4039

VL - 50

SP - 4459

EP - 4462

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 31

ER -

An amine-derivatized, DOTA-loaded polymeric support for Fmoc solid phase peptide synthesis

Abstract

Keywords

ASJC Scopus subject areas

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