An allosteric modulator of RNA binding targeting the N-terminal domain of TDP-43 yields neuroprotective properties

Keyphrases

• N-terminal Domain 100%
• RNA Binding 100%
• TAR DNA-binding Protein 43 (TDP-43) 100%
• Neuroprotective Properties 100%
• Allosteric Modulator 100%
• RNA-binding Domain 25%
• Allosteric Modulation 25%
• Incubation 12%
• Protein Level 12%
• Small Molecules 12%
• DNA-binding Proteins 12%
• Neurodegenerative Diseases 12%
• Motor Impairment 12%
• Amyotrophic Lateral Sclerosis 12%
• In Silico Docking 12%
• Transactivity 12%
• Drosophila Model 12%
• Primary Motor Neurons 12%

Biochemistry, Genetics and Molecular Biology

• N-Terminus 100%
• RNA Binding 100%
• Transactive Response Dna Binding Protein-43 100%
• RNA 33%
• TAR DNA Binding Protein 33%
• Small Molecule 16%
• DNA-binding Protein 16%
• Computer Model 16%
• Motor Neuron 16%
• Fruit Fly Model 16%
• RNA Recognition Motif 16%

Immunology and Microbiology

• Amino Terminal Sequence 100%
• RNA Binding 100%
• Transactive Response Dna Binding Protein-43 100%
• TAR DNA Binding Protein 33%
• DNA Binding Protein 16%
• Fruit Fly Model 16%
• Computer Model 16%
• RNA Recognition Motif 16%