TY - GEN
T1 - Amyloid-β Can Form Fractal Antenna-Like Networks Responsive to Electromagnetic Beating and Wireless Signaling
AU - Saxena, Komal
AU - Singh, Pushpendra
AU - Dey, Parama
AU - Wälti, Marielle Aulikki
AU - Sahoo, Pathik
AU - Ghosh, Subrata
AU - Krishnanda, Soami Daya
AU - Riek, Roland
AU - Bandyopadhyay, Anirban
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
PY - 2023
Y1 - 2023
N2 - Clathrin protein coats the deposits into vesicles, sorts and carries the cargo to the destination, thus, cleans the waste. The degraded product of the amyloid precursor protein Aβ and its aggregated fibrils are associated with Alzheimer’s disease. Why Clathrin fails to arrest the rapid aggregation is debated. Here, we demonstrate that in contact with a hexagonal-close-packed organic substrate, the Aβ(1-42) fibrils form an electromagnetically responsive fractal superstructure. Using two independent experimental techniques with microwave and laser spectroscopy, we have discovered the electric pulse generating ability (i.e., beating/interference) of the Aβ-fractal networks that fine-tune the Clathrin-mediated disassembly by inducing step-by-step morphogenesis. A fractal antenna network has multiple communication modes; beating is essential to disassemble it. Rapid multi-scale synthesis of antenna-network only in the presence of a typical geometric shape is unprecedented. Our finding sheds light on how brain deposits could suddenly outsmart the natural brain cleansing and how we could bypass the rapid propagation of Alzheimer’s.
AB - Clathrin protein coats the deposits into vesicles, sorts and carries the cargo to the destination, thus, cleans the waste. The degraded product of the amyloid precursor protein Aβ and its aggregated fibrils are associated with Alzheimer’s disease. Why Clathrin fails to arrest the rapid aggregation is debated. Here, we demonstrate that in contact with a hexagonal-close-packed organic substrate, the Aβ(1-42) fibrils form an electromagnetically responsive fractal superstructure. Using two independent experimental techniques with microwave and laser spectroscopy, we have discovered the electric pulse generating ability (i.e., beating/interference) of the Aβ-fractal networks that fine-tune the Clathrin-mediated disassembly by inducing step-by-step morphogenesis. A fractal antenna network has multiple communication modes; beating is essential to disassemble it. Rapid multi-scale synthesis of antenna-network only in the presence of a typical geometric shape is unprecedented. Our finding sheds light on how brain deposits could suddenly outsmart the natural brain cleansing and how we could bypass the rapid propagation of Alzheimer’s.
KW - Alzheimer's
KW - Amyloid Beta
KW - CHC
KW - Clathrin heavy chain
KW - Clathrin light chain
KW - CLC
KW - Electromagnetic treatment
KW - Fabry Perot interferometry
KW - Fractal
KW - Microwave
UR - https://www.scopus.com/pages/publications/85164940263
UR - https://www.scopus.com/pages/publications/85164940263#tab=citedBy
U2 - 10.1007/978-981-99-1916-1_25
DO - 10.1007/978-981-99-1916-1_25
M3 - Conference contribution
AN - SCOPUS:85164940263
SN - 9789819919154
T3 - Lecture Notes in Networks and Systems
SP - 323
EP - 344
BT - Proceedings of Trends in Electronics and Health Informatics - TEHI 2022
A2 - Mahmud, Mufti
A2 - Mendoza-Barrera, Claudia
A2 - Kaiser, M. Shamim
A2 - Bandyopadhyay, Anirban
A2 - Ray, Kanad
A2 - Lugo, Eduardo
PB - Springer Science and Business Media Deutschland GmbH
T2 - 2nd International Conference on Trends in Electronics and Health Informatics, TEHI 2022
Y2 - 7 December 2022 through 9 December 2022
ER -