Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder

Jennifer C. Britton; Evelyn Stewart; William D.S. Killgore; Isabelle M. Rosso; Lauren M. Price; Andrea L. Gold; Daniel S. Pine; Sabine Wilhelm; Michael A. Jenike; Scott L. Rauch

doi:10.1002/da.20718

Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder

Jennifer C. Britton, Evelyn Stewart, William D.S. Killgore, Isabelle M. Rosso, Lauren M. Price, Andrea L. Gold, Daniel S. Pine, Sabine Wilhelm, Michael A. Jenike, Scott L. Rauch

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. Methods: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N512) and a HC sample (N517) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety 27:643-651, 2010.

Original language	English (US)
Pages (from-to)	643-651
Number of pages	9
Journal	Depression and Anxiety
Volume	27
Issue number	7
DOIs	https://doi.org/10.1002/da.20718
State	Published - Jul 2010
Externally published	Yes

Keywords

Anxiety disorder
Disgust
FMRI
Fear
Neuroimaging
OCD

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

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10.1002/da.20718

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title = "Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder",

abstract = "Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. Methods: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N512) and a HC sample (N517) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety 27:643-651, 2010.",

keywords = "Anxiety disorder, Disgust, FMRI, Fear, Neuroimaging, OCD",

author = "Britton, {Jennifer C.} and Evelyn Stewart and Killgore, {William D.S.} and Rosso, {Isabelle M.} and Price, {Lauren M.} and Gold, {Andrea L.} and Pine, {Daniel S.} and Sabine Wilhelm and Jenike, {Michael A.} and Rauch, {Scott L.}",

year = "2010",

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doi = "10.1002/da.20718",

language = "English (US)",

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AU - Stewart, Evelyn

AU - Killgore, William D.S.

AU - Rosso, Isabelle M.

AU - Price, Lauren M.

AU - Gold, Andrea L.

AU - Pine, Daniel S.

AU - Wilhelm, Sabine

AU - Jenike, Michael A.

AU - Rauch, Scott L.

PY - 2010/7

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N2 - Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. Methods: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N512) and a HC sample (N517) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety 27:643-651, 2010.

AB - Background: Exaggerated amygdala activation to threatening faces has been detected in adults and children with anxiety disorders, compared to healthy comparison (HC) subjects. However, the profile of amygdala activation in response to facial expressions in obsessive-compulsive disorder (OCD) may be a distinguishing feature; a prior study found that compared with healthy adults, adults with OCD exhibited less amygdala activation to emotional and neutral faces, relative to fixation [Cannistraro et al. (2004). Biological Psychiatry 56:916-920]. Methods: In the current event-related functional magnetic resonance imaging (fMRI) study, a pediatric OCD sample (N512) and a HC sample (N517) performed a gender discrimination task while viewing emotional faces (happy, fearful, disgusted) and neutral faces. Results: Compared to the HC group, the OCD group showed less amygdala/hippocampus activation in all emotion and neutral conditions relative to fixation. Conclusions: Like previous reports in adult OCD, pediatric OCD may have a distinct neural profile from other anxiety disorders, with respect to amygdala activation in response to emotional stimuli that are not disorder specific. Depression and Anxiety 27:643-651, 2010.

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KW - Neuroimaging

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Amygdala activation in response to facial expressions in pediatric obsessive-compulsive disorder

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