TY - JOUR
T1 - Amphotericin B-Induced Myelopathy
AU - Carnevale, Nicholas T.
AU - Galgiani, John N.
AU - Stevens, David A.
AU - Herrick, Maie Kaarsoo
AU - Langston, J. William
PY - 1980/9
Y1 - 1980/9
N2 - Two patients with coccidioidal meningitis experienced transient neurologic deficits shortly after receiving intrathecal injections of amphotericin B. Continuation of treatment eventually led to a severe flaccid paraparesis with a thoracic sensory level in one patient, and a partial Brown-Séquard's syndrome in the other. Myelography was normal in both, with no evidence of arachnoiditis. Autopsy findings in the first patient showed a focal area of necrosis in the left half of the spinal cord consistent with the patient's clinical findings during life. The distribution of the lesion corresponded to the area supplied by a central sulcal artery. Amphotericin B may exert a direct toxic effect on the spinal cord or its vascular supply when given intrathecally.
AB - Two patients with coccidioidal meningitis experienced transient neurologic deficits shortly after receiving intrathecal injections of amphotericin B. Continuation of treatment eventually led to a severe flaccid paraparesis with a thoracic sensory level in one patient, and a partial Brown-Séquard's syndrome in the other. Myelography was normal in both, with no evidence of arachnoiditis. Autopsy findings in the first patient showed a focal area of necrosis in the left half of the spinal cord consistent with the patient's clinical findings during life. The distribution of the lesion corresponded to the area supplied by a central sulcal artery. Amphotericin B may exert a direct toxic effect on the spinal cord or its vascular supply when given intrathecally.
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U2 - 10.1001/archinte.1980.00330200065022
DO - 10.1001/archinte.1980.00330200065022
M3 - Article
C2 - 6893266
AN - SCOPUS:84948008501
SN - 0003-9926
VL - 140
SP - 1189
EP - 1192
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 9
ER -