Amphotercin B Lipid Complex Treatment of a Leukemic Child wlth Disseminated Fusarrium solani Infection

Thomas S. Patterson; Leslie L. Barton; Ziad M. Shehab; John J. Hutter

doi:10.1177/000992289603500505

Amphotercin B Lipid Complex Treatment of a Leukemic Child wlth Disseminated Fusarrium solani Infection

Thomas S. Patterson, Leslie L. Barton, Ziad M. Shehab, John J. Hutter

Pediatrics

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19 Scopus citations

Abstract

We report a case of Fusarium solani infection in a 2'2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.

Original language	English (US)
Pages (from-to)	257-260
Number of pages	4
Journal	Clinical Pediatrics
Volume	35
Issue number	5
DOIs	https://doi.org/10.1177/000992289603500505
State	Published - May 1996

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Amphotercin B Lipid Complex Treatment of a Leukemic Child wlth Disseminated Fusarrium solani Infection",

abstract = "We report a case of Fusarium solani infection in a 2'2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.",

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AB - We report a case of Fusarium solani infection in a 2'2-year-old girl with acute lymphoblastic leukemia and severe neutropenia. The infection, initially limited to her sinuses, became disseminated, as evidenced by the development of a characteristic cutaneous lesion on her left leg after a cumulative dose of amphotericin B of 18.3 mg/kg. Amphotericin B lipid complex (ABLC), 5 mg/kg/day, in conjunction with repeated surgical debridement of the sinuses and correction of neutropenia with granulocyte colony stimulating factor (GCSF), led to clinical and mycologic cure.

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Amphotercin B Lipid Complex Treatment of a Leukemic Child wlth Disseminated Fusarrium solani Infection

Abstract

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