Amelioration of nifedipine poisoning associated with glucagon therapy

Frank G. Walter; Gregory Frye; John T. Mullen; Brent R. Ekins; Paul A. Khasigian

doi:10.1016/S0196-0644(05)80998-9

Amelioration of nifedipine poisoning associated with glucagon therapy

Frank G. Walter, Gregory Frye, John T. Mullen, Brent R. Ekins, Paul A. Khasigian

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.

Original language	English (US)
Pages (from-to)	1234-1237
Number of pages	4
Journal	Annals of emergency medicine
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/S0196-0644(05)80998-9
State	Published - Jul 1993

Keywords

glucagon nifedipine

ASJC Scopus subject areas

Emergency Medicine

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10.1016/S0196-0644(05)80998-9

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abstract = "Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.",

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AU - Frye, Gregory

AU - Mullen, John T.

AU - Ekins, Brent R.

AU - Khasigian, Paul A.

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N2 - Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.

AB - Glucagon relieves calcium channel blocker-induced hypotension in animal studies. There are no published case reports of glucagon relieving hypotension in patients with calcium channel blocker poisoning. We describe a patient who developed hypotension after ingestion of 900 mg nifedipine. Therapy with IV lactated Ringer's solution and calcium chloride alone did not relieve his hypotension. However, hypotension rapidly resolved after the addition of IV glucagon therapy. This is the first case report of glucagon therapy at least temporally associated with relief of hypotension in a patient with calcium channel blocker poisoning. More research is needed to determine the appropriate role for glucagon in treating patients with calcium channel blocker poisoning.

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Amelioration of nifedipine poisoning associated with glucagon therapy

Abstract

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