AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

Keiko Hosohata; Raymond M. Quock; Yoshiaki Hosohata; Thomas H. Burkey; Alexandros Makriyannis; Paul Consroe; William R. Roeske; Henry I. Yamamura

doi:10.1016/S0024-3205(97)00596-1

AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

Keiko Hosohata, Raymond M. Quock, Yoshiaki Hosohata, Thomas H. Burkey, Alexandros Makriyannis, Paul Consroe, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [³⁵S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.

Original language	English (US)
Pages (from-to)	PL115-PL118
Journal	Life Sciences
Volume	61
Issue number	9
DOIs	https://doi.org/10.1016/S0024-3205(97)00596-1
State	Published - Jul 25 1997

Keywords

Cannabinoid antagonist
Guinea pig
[S]GTPγS binding

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/S0024-3205(97)00596-1

Cite this

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title = "AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain",

abstract = "AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.",

keywords = "Cannabinoid antagonist, Guinea pig, [S]GTPγS binding",

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note = "Funding Information: This research was supported in part by grants from the Arizona Disease Control Research Commission and N.I.D.A.",

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T1 - AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

AU - Hosohata, Keiko

AU - Quock, Raymond M.

AU - Hosohata, Yoshiaki

AU - Burkey, Thomas H.

AU - Makriyannis, Alexandros

AU - Consroe, Paul

AU - Roeske, William R.

AU - Yamamura, Henry I.

N1 - Funding Information: This research was supported in part by grants from the Arizona Disease Control Research Commission and N.I.D.A.

PY - 1997/7/25

Y1 - 1997/7/25

N2 - AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.

AB - AM630 has been demonstrated to be a cannabinoid receptor antagonist in the mouse brain and vas deferens. Conversely, it was recently reported that AM630 acts as a cannabinoid agonist in the guinea pig ileum. This research was designed to determine whether the difference in the action of AM630 is species Studies conducted in guinea pig brain reveal that AM630 antagonizes the stimulatory effect of the cannabinoid agonist WIN 55,212-2 on [35S]GTPγS binding suggesting that difference in AM630 activity in different tissues is not due to species variation.

KW - Cannabinoid antagonist

KW - Guinea pig

KW - [S]GTPγS binding

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AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain

Abstract

Keywords

ASJC Scopus subject areas

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