Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Anunya Hiranrattana; Debra A. Stern; Stefano Guerra; Marilyn Halonen; Anne L. Wright; Michael Daines; Fernando D. Martinez; Wayne J. Morgan

doi:10.1136/thoraxjnl-2017-210325

Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Anunya Hiranrattana, Debra A. Stern, Stefano Guerra, Marilyn Halonen, Anne L. Wright, Michael Daines, Fernando D. Martinez, Wayne J. Morgan

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

Original language	English (US)
Pages (from-to)	1170-1173
Number of pages	4
Journal	Thorax
Volume	73
Issue number	12
DOIs	https://doi.org/10.1136/thoraxjnl-2017-210325
State	Published - Dec 1 2018

Keywords

allergic lung disease
asthma
asthma epidemiology

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1136/thoraxjnl-2017-210325

Cite this

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title = "Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics",

abstract = "In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.",

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T1 - Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

AU - Hiranrattana, Anunya

AU - Stern, Debra A.

AU - Guerra, Stefano

AU - Halonen, Marilyn

AU - Wright, Anne L.

AU - Daines, Michael

AU - Martinez, Fernando D.

AU - Morgan, Wayne J.

PY - 2018/12/1

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N2 - In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

AB - In the non-selected birth cohort Tucson Children's Respiratory Study, early sensitisation to Alternaria was associated with increased airway hyper-responsiveness (AHR) into adult life among non-asthmatics. The increase in AHR was of a similar magnitude to that seen for Alternaria sensitised asthmatics and was primarily evident among those who were overweight or obese. In contrast, there was no significant association between early sensitisation to aeroallergens other than Alternaria and AHR among non-asthmatics. Why this group of Alternaria sensitised individuals without asthma demonstrated increased AHR of a magnitude similar to asthmatics is unknown and requires further investigation.

KW - allergic lung disease

KW - asthma

KW - asthma epidemiology

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Alternaria sensitisation at age 6 years is associated with subsequent airway hyper-responsiveness in non-asthmatics

Abstract

Keywords

ASJC Scopus subject areas

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