Abstract
Transforming growth factors β (TGF-βs) are peptides involved in autocrine and paracrine control of cell growth and differentiation. In the kidneys, TGF-β2 has been shown to localize specifically in renin-producing cells in various conditions stimulating the renin response. To test in vivo the functional role of TGF-β2, the renin response was investigated in mice heterozygous for a null mutation of the TGF-β2 gene, which had a two-fold reduction in the amount of TGF-β2 mRNA. Although the increase in plasma renin concentration triggered by dehydration was not different from wild-type mice, renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. These data suggest that TGF-β2 exerts an inhibitory effect on renin synthesis and release from the juxtaglomerular apparatuses. Copyright
Original language | English (US) |
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Pages (from-to) | 374-382 |
Number of pages | 9 |
Journal | Experimental Nephrology |
Volume | 10 |
Issue number | 5-6 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Heterozygous deficient mice
- Kidneys
- Renin synthesis and secretion
- Transforming growth factor-β
ASJC Scopus subject areas
- Nephrology