Alterations of α2 -globulin and the clinical response in patients with prostatic cancer following cryotherapy

Richard J. Ablin, Maurice J. Gonder, Ward A. Soanes

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Evaluation of alterations in the level of α2-globulin in the serum of 18 patients with prostatic cancer prior to and following cryotherapy of their primary prostatic tumor and the clinical response of these patients disclosed: (1) a progressive increase in the level of α2-globulin and the incidence of patients with significantly elevated levels of α2-globulin, i.e., > 1.30 g/100 ml, with a progression of the stage of their malignancy; (2) a decrease in the levels of α2-globulin in the serum of 14 of 18 (78%) patients following cryotherapy, and (3) a favorable clinical response in 11 of 14 (79%) patients with prostatic cancer showing a decrease in α2-globulin following cryotherapy. While limited to the study of a relatively small patient population, the present results suggest a prognostic potential for α2-globulin, particularly as applied to stage identification in prostatic cancer. Pending confirmation by evaluation of a larger patient population, it may even provide objective criteria for monitoring the clinical response of an individual following cryotherapy of the prostate.

Original languageEnglish (US)
Pages (from-to)127-144
Number of pages18
JournalOncology (Switzerland)
Issue number3-4
StatePublished - 1975
Externally publishedYes


  • Cryosurgery
  • Prostatic cancer
  • α-Globulin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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