Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm

Christine L. Miller; Victor J. Hruby; Terry O. Matsunaga; Paula C. Bickford

doi:10.1016/0196-9781(93)90128-4

Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm

Christine L. Miller, Victor J. Hruby, Terry O. Matsunaga, Paula C. Bickford

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The peptides alpha-melanocyte stimulating hormone (alpha-MSH) and melanin concentrating hormone (MCH; rat and salmon sequence) were administered to anesthetized rats by intracerebroventricular infusion. Depth recordings were carried out in the dorsal hippocampus, and auditory gating was assessed. Auditory gating in this paradigm refers to the decrease in amplitude of the second of two tone-evoked CNS potentials that can be measured when pairs of identical tones are presented 500 ms apart. Alpha-MSH increases auditory gating, whereas MCH has the opposite effect. When MCH was administered prior to alpha-MSH, the ability of alpha-MSH to increase auditory gating was blocked. Thus, the two peptides appear to be functional antagonists.

Original language	English (US)
Pages (from-to)	431-440
Number of pages	10
Journal	Peptides
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0196-9781(93)90128-4
State	Published - 1993

Keywords

Alpha-MSH
Antagonism
Central effects
Cholinergic
Dose-response
Hippocampus
ICV administration
MCH
Medial septum
Melanin concentrating hormone
Melanocyte simulating hormone
Native structure

ASJC Scopus subject areas

Biochemistry
Physiology
Endocrinology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(93)90128-4

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title = "Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm",

abstract = "The peptides alpha-melanocyte stimulating hormone (alpha-MSH) and melanin concentrating hormone (MCH; rat and salmon sequence) were administered to anesthetized rats by intracerebroventricular infusion. Depth recordings were carried out in the dorsal hippocampus, and auditory gating was assessed. Auditory gating in this paradigm refers to the decrease in amplitude of the second of two tone-evoked CNS potentials that can be measured when pairs of identical tones are presented 500 ms apart. Alpha-MSH increases auditory gating, whereas MCH has the opposite effect. When MCH was administered prior to alpha-MSH, the ability of alpha-MSH to increase auditory gating was blocked. Thus, the two peptides appear to be functional antagonists.",

keywords = "Alpha-MSH, Antagonism, Central effects, Cholinergic, Dose-response, Hippocampus, ICV administration, MCH, Medial septum, Melanin concentrating hormone, Melanocyte simulating hormone, Native structure",

author = "Miller, {Christine L.} and Hruby, {Victor J.} and Matsunaga, {Terry O.} and Bickford, {Paula C.}",

note = "Funding Information: This work was supported by USPHS grants MH38321 and MH44212; by the Veterans Administration Center Medical Research Service (PCB); by a grant to Christine L. Miller from the Stanley Foundation; and by U.S. Public Health Service Grant DK-17420 (V.J.H.).",

year = "1993",

doi = "10.1016/0196-9781(93)90128-4",

language = "English (US)",

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pages = "431--440",

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AU - Miller, Christine L.

AU - Hruby, Victor J.

AU - Matsunaga, Terry O.

AU - Bickford, Paula C.

N1 - Funding Information: This work was supported by USPHS grants MH38321 and MH44212; by the Veterans Administration Center Medical Research Service (PCB); by a grant to Christine L. Miller from the Stanley Foundation; and by U.S. Public Health Service Grant DK-17420 (V.J.H.).

PY - 1993

Y1 - 1993

N2 - The peptides alpha-melanocyte stimulating hormone (alpha-MSH) and melanin concentrating hormone (MCH; rat and salmon sequence) were administered to anesthetized rats by intracerebroventricular infusion. Depth recordings were carried out in the dorsal hippocampus, and auditory gating was assessed. Auditory gating in this paradigm refers to the decrease in amplitude of the second of two tone-evoked CNS potentials that can be measured when pairs of identical tones are presented 500 ms apart. Alpha-MSH increases auditory gating, whereas MCH has the opposite effect. When MCH was administered prior to alpha-MSH, the ability of alpha-MSH to increase auditory gating was blocked. Thus, the two peptides appear to be functional antagonists.

AB - The peptides alpha-melanocyte stimulating hormone (alpha-MSH) and melanin concentrating hormone (MCH; rat and salmon sequence) were administered to anesthetized rats by intracerebroventricular infusion. Depth recordings were carried out in the dorsal hippocampus, and auditory gating was assessed. Auditory gating in this paradigm refers to the decrease in amplitude of the second of two tone-evoked CNS potentials that can be measured when pairs of identical tones are presented 500 ms apart. Alpha-MSH increases auditory gating, whereas MCH has the opposite effect. When MCH was administered prior to alpha-MSH, the ability of alpha-MSH to increase auditory gating was blocked. Thus, the two peptides appear to be functional antagonists.

KW - Alpha-MSH

KW - Antagonism

KW - Central effects

KW - Cholinergic

KW - Dose-response

KW - Hippocampus

KW - ICV administration

KW - MCH

KW - Medial septum

KW - Melanin concentrating hormone

KW - Melanocyte simulating hormone

KW - Native structure

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JO - Peptides

JF - Peptides

IS - 3

ER -

Alpha-MSH and MCH are functional antagonists in a CNS auditory gating paradigm

Abstract

Keywords

ASJC Scopus subject areas

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